Browse the search results

Page 3 of 133
    1. Cancer Biology

    Science Forum: Challenges in validating candidate therapeutic targets in cancer

    Jeffrey Settleman et al.
    More than 30 published articles have suggested that a protein kinase called MELK is an attractive therapeutic target in human cancer, but three recent reports describe compelling evidence that it is not.
    1. Evolutionary Biology

    Evolution: Oxygen and early animals

    Kalle T Rytkönen
    The biology of sponges provides clues about how early animals may have dealt with low levels of oxygen.
    Insight
    Available as:
    • HTML
    • PDF
    1. Ecology
    2. Human Biology and Medicine

    Point of View: A transatlantic perspective on 20 emerging issues in biological engineering

    Bonnie C Wintle et al.
    Horizon scanning has been used to identify opportunities and risks presented by 20 emerging issues in the field of biological engineering.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Biofilms: Flipping the switch

    Xavier Pierrat, Alexandre Persat
    A structural switch controls the architecture of Vibrio cholerae biofilms by mediating the interactions between two matrix components.
    Insight
    Available as:
    • HTML
    • PDF
    1. Cell Biology
    2. Human Biology and Medicine

    Prostate Cancer: SPOP the mutation

    Leah Rider, Scott D Cramer
    Insight
    Available as:
    • HTML
    • PDF
    1. Biochemistry and Chemical Biology

    Cell Biology: Opening up new fronts in the fight against cholesterol

    Russell A DeBose-Boyd, Jay D Horton
    Insight
    Available as:
    • HTML
    • PDF
    1. Cancer Biology
    2. Human Biology and Medicine

    Cancer Therapeutics: Partial loss of genes might open therapeutic window

    Bo Liu, Omar Abdel-Wahab
    The loss of genes that encode RNA splicing factors weakens cancer cells in a way that could be exploited by new approaches to treatment.
    Insight
    Available as:
    • HTML
    • PDF
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Science Forum: Viral factors in influenza pandemic risk assessment

    Marc Lipsitch et al.
    We identify key strengths and limitations in use of viral genotyping and phenotyping to estimate pandemic risk from influenza A viruses, focusing on 3 traits, hemagglutinin binding specificity, hemagglutinin pH of activation, and polymerase complex efficiency.
    1. Chromosomes and Gene Expression

    Unfolded Protein Response: Silence without stress

    David J Young, Nicholas R Guydosh
    Insight
    Available as:
    • HTML
    • PDF