4,260 results found
    1. Genetics and Genomics
    2. Neuroscience

    The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing

    Shahar Alon et al.
    The first example of an animal where RNA-editing dramatically reshapes the entire proteome demonstrates that editing must be a critical evolutionary and adaptive force.
    1. Genetics and Genomics

    RNA-programmed genome editing in human cells

    Martin Jinek et al.
    A bacterial protein can be programmed with short RNA molecules to stimulate genome editing at specific sites in human cells.
    1. Chromosomes and Gene Expression

    The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis

    Sarah N Deffit et al.
    Identification of tissue-specific RNA editing using a robust, publicly-available platform (SAILOR) reveals noncoding A-to-I editing events required for proper gene expression and neurological function, significantly advancing the understanding of how ADARs function in neural cells.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

    Yize Li et al.
    Endogenous double-stranded RNA is generated in human cells and leads to RNase L activation and consequent cell death unless neutralized by adenosine deaminase acting on RNA1 (ADAR1).
    1. Microbiology and Infectious Disease

    A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

    Alyson Ashe et al.
    Evidence that C. elegans and mammals use homologous versions of the same protein (RIG-1) to activate antiviral defense mechanisms suggests that RIG-1 may have a conserved role in coupling virus recognition to virus destruction.
    1. Genetics and Genomics

    A new genus of horse from Pleistocene North America

    Peter D Heintzman et al.
    The extinct stilt-legged equids of North America are not related to Asiatic asses or horses, but instead represent a distinct lineage outside of living equid diversity that became extinct in the terminal Pleistocene.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    High-throughput engineering of a mammalian genome reveals building principles of methylation states at CG rich regions

    Arnaud R Krebs et al.
    Large numbers of DNA sequence variants comprehensively define how transcription factor binding sites and CG density preserve mammalian promoters from repression by DNA methylation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of transcription arrest by coliphage HK022 Nun in an Escherichia coli RNA polymerase elongation complex

    Jin Young Kang et al.
    Cryo-electron microscopy structures show how coliphage HK022 Nun blocks Escherichia coli RNA polymerase translocation by mediating multiple interactions between the RNA polymerase and nucleic acids.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering

    Kunwoo Lee et al.
    The guide RNA and donor DNA of the CRISPR/Cas system tolerate large chemical modifications and can be engineered for enhanced delivery and gene editing.
    1. Chromosomes and Gene Expression

    Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis

    Todd Blevins et al.
    The 24-nucleotide long siRNAs that guide cytosine methylation in Arabidopsis are made by dicing short double-stranded RNAs that are only around 30 nucleotides long.

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