Browse the search results

Page 3 of 704
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3

    Ho-Ryun Chung et al.
    PHF13 interacts with transcriptional complexes containing RNA polymerase II to recruit/stabilize them at H3K4me2/3 containing active or bivalent promoters.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into the mechanism of the DEAH-box RNA helicase Prp43

    Marcel J Tauchert et al.
    The structural and functional analysis of the ATP-dependent RNA helicase Prp43 provides insights into the mechanisms of RNA binding and translocation, which could serve as paradigm for all DEAH-box proteins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals

    Yuling Li et al.
    Animal RanBP1 nuclear export and cargo dissociation mechanisms are surprisingly different from yeast, due to mutations of critical residues, leading to greater nuclear transport efficiency and higher energy cost.
    1. Cancer Biology

    KRAS-dependent sorting of miRNA to exosomes

    Diana J Cha et al.
    In isogenically matched colorectal cancer (CRC) cell lines, mutant KRAS alters the composition of secreted miRNAs in extracellular vesicles that can then transfer repressive activity to wild type cells.
    1. Cancer Biology
    2. Cell Biology

    A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing

    Francesca Angiolini et al.
    Endothelial cells express a soluble isoform of the L1CAM cell adhesion molecule that is generated by the splicing factor NOVA2 and induces angiogenesis, with relevant implications for ovarian cancer vascularization.
    1. Genetics and Genomics
    2. Neuroscience

    Hypothalamic transcriptomes of 99 mouse strains reveal trans eQTL hotspots, splicing QTLs and novel non-coding genes

    Yehudit Hasin-Brumshtein et al.
    In depth characterization of gene expression in the mouse hypothalamus will facilitate understanding of the molecular pathways that affect metabolic traits and discovers new genes associated with these pathways.
    1. Cell Biology
    2. Neuroscience

    C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import

    Lindsey R Hayes et al.
    Poly-PR and poly-GR interact with importin β, disrupt importin-cargo loading, and inhibit nuclear import in permeabilized cells in a manner that can be rescued by RNA.
    1. Chromosomes and Gene Expression

    piRNA-guided co-transcriptional silencing coopts nuclear export factors

    Martin H Fabry et al.
    A member of the Drosophila Nuclear Export Factor (Nxf) family, Nxf2, forms part of the piRNA-dependent co-transcriptional silencing complex and is essential for transposon repression in fly ovaries.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Dna2 nuclease-helicase structure, mechanism and regulation by Rpa

    Chun Zhou et al.
    X-ray crystallography reveals that the Dna2 nuclease-helicase contains a long tunnel through which single-stranded DNA threads, and an allosteric mechanism for displacing the DNA-binding protein Rpa that restricts cleavage to the proper polarity.
    1. Evolutionary Biology

    Intermolecular epistasis shaped the function and evolution of an ancient transcription factor and its DNA binding sites

    Dave W Anderson et al.
    Experimental mapping of the joint sequence space of an ancient transcription factor (TF) and its DNA binding sites reveals that epistasis across the molecular interface permitted the evolution of a new and specific TF-DNA complex.