806 results found
    1. Cell Biology
    2. Genetics and Genomics

    Endogenous RNA interference is driven by copy number

    Cristina Cruz, Jonathan Houseley
    The ability to target transcripts from high-copy regions of the genome is an emergent property of a minimal RNA interference system.
    1. Chromosomes and Gene Expression

    Transcription of a 5’ extended mRNA isoform directs dynamic chromatin changes and interference of a downstream promoter

    Minghao Chia et al.
    Expression of a 5' extended mRNA isoform represses transcription of a downstream promoter.
    1. Biochemistry and Chemical Biology
    2. Ecology

    ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetles

    Anja S Strauss et al.
    A transport protein enables leaf beetle larvae to take up and store plant toxins and use them as part of their own defense strategy.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Efficient termination of nuclear lncRNA transcription promotes mitochondrial genome maintenance

    Dorine Jeanne Mariëtte du Mee et al.
    RNA Polymerase II transcriptional termination of a nuclear long non-coding RNA is required to maintain the mitochondrial genome and hence promotes budding yeast growth.
    1. Microbiology and Infectious Disease

    A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity

    Alyson Ashe et al.
    Evidence that C. elegans and mammals use homologous versions of the same protein (RIG-1) to activate antiviral defense mechanisms suggests that RIG-1 may have a conserved role in coupling virus recognition to virus destruction.
    1. Cell Biology
    2. Developmental Biology

    The beetle amnion and serosa functionally interact as apposed epithelia

    Maarten Hilbrant et al.
    Late morphogenesis of the insect extraembryonic epithelia involves transient formation of a basal-basal bilayer to coordinate the functional contributions of two discrete tissues.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

    Victoria E Pedanou et al.
    A large-scale RNA interference screen uncovers a new transcriptional regulatory program involving the histone H3 demethylase KDM3A, which mediates detachment-induced apoptosis (anoikis) in breast epithelial cells.
    1. Chromosomes and Gene Expression

    CRISPRi is not strand-specific at all loci and redefines the transcriptional landscape

    Françoise S Howe et al.
    CRISPR interference (CRISPRi), which uses small guide RNAs to target catalytically dead Cas9 protein to chromatin, disrupts existing transcription units and generates new sites for initiation and termination of transcription on both strands of DNA.
    1. Developmental Biology
    2. Evolutionary Biology

    Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita

    Karl R Wotton et al.
    Quantitative system-level analysis of a pattern-forming gene regulatory network in a non-model organism shows that dynamic changes in gene expression evolve through quantitative system drift.

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