1,311 results found
    1. Cancer Biology

    The identification of dual protective agents against cisplatin-induced oto- and nephrotoxicity using the zebrafish model

    Jaime N Wertman et al.
    L-mimosine and dopamine protect against cisplatin-induced oto- and nephrotoxicity in zebrafish and human cell line models.
    1. Neuroscience

    Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

    Trisha V Vaidyanathan et al.
    Cortical astrocytes play key roles in NREM sleep by regulating sleep depth and duration through separate GPCR pathways, and differentially control neuronal slow-wave activity in local and remote cortical circuits.
    1. Cell Biology
    2. Immunology and Inflammation

    Deep-learning-based three-dimensional label-free tracking and analysis of immunological synapses of CAR-T cells

    Moosung Lee et al.
    Rapid, label-free, volumetric, and automated assessment of the immunological synapse dynamics is demonstrated by combining optical diffraction tomography and deep-learning-based segmentation, providing a new option for immunological research.
    1. Cell Biology
    2. Developmental Biology

    Growth cone-localized microtubule organizing center establishes microtubule orientation in dendrites

    Xing Liang et al.
    In Caenorhabditis elegans, dendrites establish their unique microtubule polarity by localizing an organizing center behind the growing tip.
    1. Neuroscience

    Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo

    Peter James Morgan et al.
    Short, theta-bursts of action potential firing decrease the global excitability of CA1 pyramidal neurons, providing an internal mechanism which could regulate their allocation to memory engrams.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Dynamic change of electrostatic field in TMEM16F permeation pathway shifts its ion selectivity

    Wenlei Ye et al.
    TMEM16F shifts its ion selectivity in response to change of intracellular Ca2+, membrane potential and ionic strength.
    1. Cell Biology
    2. Developmental Biology

    Super-resolution microscopy reveals coupling between mammalian centriole subdistal appendages and distal appendages

    Weng Man Chong et al.
    Super-resolved architectural framework of subdistal appendages surprisingly reveals coupling between distal appendages and subdistal appendages.
    1. Cell Biology
    2. Immunology and Inflammation

    A two-hybrid antibody micropattern assay reveals specific in cis interactions of MHC I heavy chains at the cell surface

    Cindy Dirscherl et al.
    A generally applicable two-hybrid assay demonstrates that MHC class I heavy chains devoid of beta-2 microglobulin associate within and across allotypes, with implications for endocytosis and autoimmunity.
    1. Plant Biology

    Pathogen effectors and plant immunity determine specialization of the blast fungus to rice subspecies

    Jingjing Liao et al.
    Specialized fungal pathogen populations infect rice varieties with contrasting immune systems co-cultivated in a traditional agro-system, indicating the relevance of crop diversity to restricting epidemics in the landscape.
    1. Cell Biology

    Regulation of the PI3K pathway through a p85α monomer–homodimer equilibrium

    Lydia WT Cheung et al.
    The p85α homodimer plays a role in the PI3K pathway by regulating PTEN function.

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