4,462 results found
    1. Cell Biology

    Spatial control of translation repression and polarized growth by conserved NDR kinase Orb6 and RNA-binding protein Sts5

    Illyce Nuñez et al.
    NDR kinase Orb6 prevents RNP granule assembly and translational repression by promoting Sts5 association with 14-3-3 protein Rad24 to spatially control polarized cell growth.
    1. Genetics and Genomics

    PRD-2 directly regulates casein kinase I and counteracts nonsense-mediated decay in the Neurospora circadian clock

    Christina M Kelliher et al.
    Casein kinase I, a pivotal kinase in the circadian clock encoded by ck-1a, is positively regulated by a novel RNA-binding protein that protects ck-1a transcripts from nonsense-mediated decay.
    1. Cell Biology
    2. Developmental Biology

    Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation

    Masatoshi Hara et al.
    The kinase that controls maternal mRNA translation is regulated by phosphorylation of its activating subunit to restrict kinase activity to the developmental window between meiosis completion and early embryogenesis.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

    Jirka Peschek, Peter Walter
    Interconnected RNA processing mechanisms ensure the fidelity of non-conventional mRNA splicing during the unfolded protein response.
    1. Cancer Biology

    CD95/Fas ligand mRNA is toxic to cells

    Will Putzbach et al.
    The mRNA of the apoptosis inducing death ligand CD95L/FasL kills cancer cells through RNAi after conversion into small RNAs that are loaded into the RNA-induced Silencing Complex.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

    Jennifer Jung et al.
    An image-based multiplex autophagosome RNAi screen targeting all Rab GTPases as well as their GAPs and GEFs identifies the Rab GEF SMCR8 as multifaceted autophagy modulator, which regulates kinase activity and gene expression of ULK1.
    1. Chromosomes and Gene Expression

    Rad53 checkpoint kinase regulation of DNA replication fork rate via Mrc1 phosphorylation

    Allison W McClure, John FX Diffley
    DNA replication fork rate in budding yeast is regulated in response to DNA damage by phosphorylation of two proteins, Mrc1 and Mcm10, by the Rad53 protein kinase.
    1. Biochemistry and Chemical Biology

    Allosteric mechanism of the V. vulnificus adenine riboswitch resolved by four-dimensional chemical mapping

    Siqi Tian et al.
    A new biochemical method tests whether or not the pre-existing RNA structural correlations couple small molecule binding to gene expression in a paradigmatic riboswitch.
    1. Cell Biology
    2. Developmental Biology

    The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules

    Emir E Avilés-Pagán et al.
    The Drosophila PNG kinase controls mRNA translation at the oocyte-to-embryo transition, and its GNU activating subunit is shown here to bind translational repressors and be a component of RNP granules.
    1. Chromosomes and Gene Expression

    TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

    Remi Sonneville et al.
    The TRAIP ubiquitin ligase is required during mitosis to disassemble the replisome at sites of incomplete DNA replication, and activate the mitotic DNA repair pathway, thus preserving genome integrity.

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