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    1. Neuroscience

    DMT alters cortical travelling waves

    Andrea Alamia et al.
    Psychedelics induce a pattern of cortical activity very similar to the one observed during visual perception, despite participants had shut eyes.
    1. Structural Biology and Molecular Biophysics

    New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket

    Simon Vu et al.
    Novel capsaicin analogs with conserved chemistry but varying sizes were used as molecular rulers to investigate energetics of conformational changes in the ligand-binding pocket and mechanisms of TRPV1 ligand-gating.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells

    Osama F Harraz et al.
    TRPV4 channels in brain capillaries are suppressed by the phosphoinositide PIP2 and activated by receptor agonists implicated in neurovascular coupling.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

    Melesse Nune et al.
    The histone chaperone FACT and the deubiquitinating enzyme Ubp10 act in concert to remove ubiquitin from histone H2B in nucleosomes, and likely coordinate nucleosome assembly during DNA replication and transcription.
    1. Structural Biology and Molecular Biophysics

    Structural basis for isoform-specific kinesin-1 recognition of Y-acidic cargo adaptors

    Stefano Pernigo et al.
    X-ray crystallography reveals how kinesin-1 recognises a novel class of cargo adaptor motifs in an isoform-specific manner.
    1. Neuroscience

    Spatial cell firing during virtual navigation of open arenas by head-restrained mice

    Guifen Chen et al.
    A mouse virtual reality system is presented which allows normal spatial behavior and place, grid and head-direction cell firing patterns in 2-D arenas, and is compatible with electrophysiology and multi-photon imaging.
    1. Developmental Biology

    Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

    Maria C Marchetto et al.
    Using iPSCs as a model to study neurodevelopmental differences between human and nonhuman primates lays the groundwork for understanding aspects of human brain evolution and neurological disease susceptibility.
    1. Developmental Biology

    Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient

    Lijuan Du et al.
    FGF morphogen gradient self-generates a recipient tissue-specific contour by feedback-regulating its cytoneme-mediated dispersion.
    1. Neuroscience

    Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery

    Ryan T Dosumu-Johnson et al.
    Pet1 neurons actively maintain cardiorespiratory tone and dynamic range in mouse neonates and critically support the recovery response to apneas, informing brain findings in the sudden infant death syndrome.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Mi-2/NuRD complex protects stem cell progeny from mitogenic Notch signaling

    Evanthia Zacharioudaki et al.
    Depleting Mi-2 in the progeny of neural stem cells prevents normal enhancer decommissioning so that they become sensitive to Notch activity and re-acquire stem cell properties.