2,493 results found
    1. Chromosomes and Gene Expression

    Kinetic competition during the transcription cycle results in stochastic RNA processing

    Antoine Coulon et al.
    Real-time single-molecule visualization of transcription and splicing in living cells reveals that RNA synthesis and processing can occur through multiple pathways on the same gene.
    1. Cell Biology
    2. Neuroscience

    Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

    Piergiorgio La Rosa et al.
    The RNA binding protein Sam68 links a key metabolic route to the neural stem cell fate in the developing mouse brain.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Arabidopsis RNA processing factor SERRATE regulates the transcription of intronless genes

    Corinna Speth et al.
    Arabidopsis RNA processing factor SERRATE associates with the chromatin of intronless genes, which are usually expressed at low levels, to enhance polymerase II association.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pat1 promotes processing body assembly by enhancing the phase separation of the DEAD-box ATPase Dhh1 and RNA

    Ruchika Sachdev et al.
    The protein Pat1 functions in the assembly of processing bodies, cellular membraneless organelles, by promoting the liquid–liquid phase separation of the DEAD-box ATPase Dhh1 and RNA.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

    Madara Ratnadiwakara et al.
    RNA-binding protein SRSF3 mediates critical changes in RNA processing of pluripotency genes, which reveals functional consequences of regulated RNA processing during stem cell self-renewal and early development.
    1. Chromosomes and Gene Expression

    RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit

    Laura Milligan et al.
    Ubiquitination close to the active site of RNAPII occurs in response to RNA processing events and is linked to transcriptional pausing, which is released following Bre5-Ubp3 mediated deubiquitination associated with the nascent transcript.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

    Jirka Peschek, Peter Walter
    Interconnected RNA processing mechanisms ensure the fidelity of non-conventional mRNA splicing during the unfolded protein response.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

    Ilaria Pettinati et al.
    MBLAC1 is an endoribonuclease specific for replication dependent histone pre-mRNA processing during S-phase and may represent a new type of cancer target.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ATPase activity of the DEAD-box protein Dhh1 controls processing body formation

    Christopher Frederick Mugler et al.
    The ATPase Dhh1 controls processing body formation and disassembly in yeast cells, and processing body dynamics can be recapitulated in vitro with recombinant Dhh1, ATP and RNA.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A RanGTP-independent mechanism allows ribosomal protein nuclear import for ribosome assembly

    Sabina Schütz et al.
    The Tsr2 carrier protein connects the nuclear import machinery with the ribosome assembly pathway.

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