3,166 results found
    1. Computational and Systems Biology

    Spectral clustering of risk score trajectories stratifies sepsis patients by clinical outcome and interventions received

    Ran Liu et al.
    Spectral clustering applied to risk trajectories of sepsis patients discovered four distinct clusters stratified by risk of septic shock, mortality, and treatments received prior to an abrupt physiological transition.
    1. Neuroscience

    Empathic pain evoked by sensory and emotional-communicative cues share common and process-specific neural representations

    Feng Zhou et al.
    Machine learning analyses reveal that the observation of acute pain inflictions and facial expressions of pain evoke shared pain-specific neural representations.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    An ER translocon for multi-pass membrane protein biogenesis

    Philip T McGilvray et al.
    A set of ER-localized membrane proteins whose loss causes developmental diseases in humans, assemble with Sec61 into a translocon that facilitates the biogenesis of hundreds of different multi-pass membrane proteins.
    1. Neuroscience

    Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors

    Yulan Li et al.
    A new strategy of memory consolidation disruption based on astrocyte and purinergic signaling, which leads to persistent fear memory attenuation accompanied by reduced fear-related anxiety behavior.
    1. Microbiology and Infectious Disease

    The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching

    Brittany L Carroll et al.
    In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..
    1. Computational and Systems Biology

    Inherent regulatory asymmetry emanating from network architecture in a prevalent autoregulatory motif

    Md Zulfikar Ali et al.
    Network architecture and physiological features of the cell dictate asymmetric gene regulation between a negative autoregulatory TF gene and its target gene.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Neuroscience

    Dynamic encoding of social threat and spatial context in the hypothalamus

    Piotr Krzywkowski et al.
    Threat and context-responsive neurons in the ventromedial hypothalamus are reshaped by experience to drive social avoidance.
    1. Chromosomes and Gene Expression

    Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments

    Hajnalka L Pálinkás et al.
    Human genomic DNA contains uracil in the late replicating, constitutive heterochromatic regions, while treatment with drugs perturbing thymidylate biosynthesis shifts the uracil distribution pattern towards the euchromatin in UNG-inhibited cells.
    1. Computational and Systems Biology

    Removing unwanted variation with CytofRUV to integrate multiple CyTOF datasets

    Marie Trussart et al.
    CytofRUV is a computational algorithm that effectively enables batch effect reduction in multiple CyTOF batches with an adaptable normalisation method and an R-Shiny application with diagnostics plots.

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