2,004 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking

    Thomas Pohlmann et al.
    An endosomal component employs a novel PAM2-like motif to recruit a key RNA-binding protein, which explains how mRNAs and associated ribosomes are attached to endosomes during coupled transport.
    1. Cell Biology

    RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs

    Mark A McClintock et al.
    Reconstitution of dynein-based mRNA transport with purified components reveals a pivotal role of an RNA localisation signal in controlling the assembly and activity of the translocation machinery.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

    Konstadinos Moissoglu et al.
    RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.
    1. Structural Biology and Molecular Biophysics

    Recruitment of two dyneins to an mRNA-dependent Bicaudal D transport complex

    Thomas E Sladewski et al.
    mRNA cargo orchestrates the activation of an in vitro reconstituted dynein-dynactin-Bicaudal D-Egalitarian complex for robust processive motion on microtubules.
    1. Cell Biology

    GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function

    Alondra Schweizer Burguete et al.
    Expanded repeat RNAs associated with human neurodegenerative diseases can become incorporated into transported granules in neurons, perturbing their function to cause neuritic branching defects.
    1. Cell Biology
    2. Physics of Living Systems

    Cortical microtubule nucleation can organise the cytoskeleton of Drosophila oocytes to define the anteroposterior axis

    Philipp Khuc Trong et al.
    A three-dimensional description of the cytoskeletal arrangement, cytoplasmic flows, and cargo transport in stage 9 Drosophila oocytes accurately reproduces mRNA localizations in wild-type and mutant oocytes.
    1. Cell Biology
    2. Neuroscience

    Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome

    Sangmok Kim, Kelsey C Martin
    The spatial regulation of gene expression within neurons occurs primarily at the level of local translation rather than by stimulus-induced RNA targeting from nucleus to synapse.
    1. Cell Biology
    2. Developmental Biology

    bicoid mRNA localises to the Drosophila oocyte anterior by random Dynein-mediated transport and anchoring

    Vítor Trovisco et al.
    The localisation of bicoid mRNA depends on its microtubule-independent anchoring at the oocyte anterior.
    1. Cell Biology

    The influence of dynein processivity control, MAPs, and microtubule ends on directional movement of a localising mRNA

    Harish Chandra Soundararajan, Simon L Bullock
    In vitro reconstitution of mRNA motility reveals the basis of directionally biased motion by groups of motors, their response to potential obstacles, and the consequences of reaching microtubule ends.
    1. Structural Biology and Molecular Biophysics

    Structure of a type IV pilus machinery in the open and closed state

    Vicki AM Gold et al.
    Electron cryo-tomography reveals a huge conformational change in the secretin domain of the type IV pilus machinery that occurs when the channel opens for pilus extrusion.

Refine your results by:

Type
Research categories