5,992 results found
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments

    Alexander Borodavka et al.
    In rotaviruses, the selective packaging of eleven distinct genomic RNA segments requires virus-encoded protein NSP2 to alter the RNA structures, facilitating their interactions with each other.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

    Ira Alexandra Iosub et al.
    High-throughput RNA-RNA interaction analysis uncovers many novel sRNA-target interactions at various growth stages in Escherichia coli.
    1. Cell Biology

    In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates

    Weirui Ma et al.
    Binding of a multivalent RNA-binding protein to mRNAs that are able to form pervasive RNA–RNA interactions induces formation of mesh-like condensates, whereas binding of mostly structured mRNAs induces sphere-like condensates.
    1. Structural Biology and Molecular Biophysics

    Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA

    Diana M Mitrea et al.
    Nucleolar protein localization involves the phase separation within the nucleolar matrix via three types of multivalent features: acidic tracts, nucleic acid binding domains and arginine-rich low complexity sequences.
    1. Microbiology and Infectious Disease

    Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

    Jennifer L Elliott et al.
    HIV-1 integrase-RNA interactions account for the key role of integrase in particle maturation.
    1. Physics of Living Systems

    Negative reciprocity, not ordered assembly, underlies the interaction of Sox2 and Oct4 on DNA

    John W Biddle et al.
    Rigorous reanalysis of single-molecule data yields evidence for energy expenditure in the interaction of transcription factors on DNA.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Avoidance of stochastic RNA interactions can be harnessed to control protein expression levels in bacteria and archaea

    Sinan Uğur Umu et al.
    Stochastic mRNA and non-coding RNA hybridisation has a major impact on protein expression.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Phosphorylation-mediated interactions with TOPBP1 couple 53BP1 and 9-1-1 to control the G1 DNA damage checkpoint

    Nicolas Bigot et al.
    Two phosphorylation sites on 53BP1 are found to mediate interaction with TOPBP1-RAD9 and shown to be essential for assembling the G1 DNA damage checkpoint response apparatus.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes

    Roberto Bonasio et al.
    The Polycomb group protein SCML2 contributes to the assembly and gene silencing function of Polycomb Repressive Complex 1 (PRC1) and requires an RNA-binding region to reach chromatin targets.
    1. Neuroscience
    2. Microbiology and Infectious Disease

    Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice

    Roman M Stilling et al.
    Social-interaction impairment in germ-free mice is associated with a markedly altered transcriptional response to social novelty in the amygdala, as characterised by replacement of upregulation of common stimulus-induced pathways with upregulation of the splicing machinery.

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