6,386 results found
    1. Genetics and Genomics
    2. Neuroscience

    Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice

    Marina Kovalenko et al.
    Genetic knockout of Hdac2 modifies molecular and cellular phenotypes in Huntington’s disease mice and has a prominent transcriptional regulatory role in adult medium spiny neurons.
    1. Developmental Biology
    2. Evolutionary Biology

    Secondary ossification center induces and protects growth plate structure

    Meng Xie et al.
    The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.
    1. Cell Biology
    2. Biochemistry and Chemical Biology

    Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin

    Melissa V Gammons et al.
    An unusual molecular mechanism has been revealed based on ultrastable histidine cluster co-aggregation underlying feedback control of an ancient cell communication pathway.
    1. Genetics and Genomics
    2. Medicine

    Patient-specific genomics and cross-species functional analysis implicate LRP2 in hypoplastic left heart syndrome

    Jeanne L Theis et al.
    Hypoplastic left heart syndrome is reflected by reduced proliferative capacity of patient iPSC-derived cardiomyocytes and requires the activity of LRP2/APOB proteins, likely in conjunction with SHH and WNT signaling pathways.
    1. Computational and Systems Biology
    2. Neuroscience

    Training deep neural density estimators to identify mechanistic models of neural dynamics

    Pedro J Gonçalves et al.
    Deep neural networks can be trained to automatically find mechanistic models which quantitatively agree with experimental data, providing new opportunities for building and visualizing interpretable models of neural dynamics.
    1. Biochemistry and Chemical Biology

    A novel DNA primase-helicase pair encoded by SCCmec elements

    Aleksandra Bebel et al.
    SCCmec genomic islands encode a novel primase-helicase pair in which priming ability is conferred upon an A-family DNA polymerase domain by a novel protein cofactor.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity

    Mark Shaaya et al.
    Light-sensitive allosteric switch module, a broadly applicable protein engineering method, is used for the regulation of protein activity with tight temporal control and spatial precision.
    1. Neuroscience

    DMT alters cortical travelling waves

    Andrea Alamia et al.
    Psychedelics induce a pattern of cortical activity very similar to the one observed during visual perception, despite participants had shut eyes.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon–anticodon pairing

    Eric D Hoffer et al.
    Chemical modifications near the tRNA anticodon and specific mRNA–tRNA pairs combine to control the ribosomal three-nucleotide mRNA reading frame, essential for the sequential addition of amino acids into polypeptide chains.

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