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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Allosteric inhibition of a stem cell RNA-binding protein by an intermediary metabolite

    Carina C Clingman, Laura M Deveau ... Sean P Ryder
    The RNA-binding protein MSI1, which is required for stem cell and cancer cell proliferation in the brain and epithelial tissues, also directly senses the concentration of long non-esterified omega-9 fatty acids.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

    Michael Zavortink, Lauren N Rutt ... Olivia S Rissland
    In fruit flies, maternally deposited RNA-binding proteins are removed during the maternal-to-zygotic transition via a mechanism of translational upregulation of Kondo, the key E2 enzyme, at egg activation.
    1. Chromosomes and Gene Expression

    Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determine C. elegans sex

    Behnom Farboud, Catherine S Novak ... Barbara J Meyer
    RNA binding protein FOX-1 functions as a dose-dependent X-signal element to communicate X-chromosome number and determine nematode sex by controlling alternative non-productive pre-mRNA splicing of the master sex-determination switch gene.
    1. Chromosomes and Gene Expression

    The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals

    Lotte Victoria Winther Stagsted, Eoghan Thomas O'Leary ... Thomas Birkballe Hansen
    Transcriptome and eCLIP analyses in mouse and human reveal splicing factor proline/glutamine rich (SFPQ) as a conserved and critical guardian of long-intron integrity, splicing, and circular RNA (circRNA) production.
    1. Cell Biology

    Two RNA-binding proteins mediate the sorting of miR223 from mitochondria into exosomes

    Liang Ma, Jasleen Singh, Randy Schekman
    Mitochondria serve as a reservoir for the sorting of an miRNA into P-bodies and from there into exosomes secreted from human cultured cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins

    Mathew Thayer, Michael B Heskett ... Phillip A Yates
    Molecular genetic analyses of ASARs reveals regulation of large-scale mammalian chromosome structure and function that includes long non-coding RNAs and nuclear RNA binding proteins as essential regulators of chromosome dynamics.
    1. Chromosomes and Gene Expression

    An ancient germ cell-specific RNA-binding protein protects the germline from cryptic splice site poisoning

    Ingrid Ehrmann, James H Crichton ... David J Elliott
    Cell division by meiosis during sperm production depends on expression of an RNA-binding protein that prevents abnormal RNA-processing pathways.
    1. Biochemistry and Chemical Biology

    RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

    Michael W Webster, James AW Stowell, Lori A Passmore
    Biochemical reconstitution of deadenylation and analysis of binding kinetics reveals how RNA-binding proteins select their mRNA targets.
    1. Developmental Biology

    The role of Imp and Syp RNA-binding proteins in precise neuronal elimination by apoptosis through the regulation of transcription factors

    Wenyue Guan, Ziyan Nie ... Jonathan Enriquez
    Genetic manipulations reveal how the spatiotemporal expression pattern of two RNA-binding proteins regulates the eventual number of motoneurons in a Drosophila neuronal lineage.
    1. Developmental Biology
    2. Genetics and Genomics

    Splicing in a single neuron is coordinately controlled by RNA binding proteins and transcription factors

    Morgan Thompson, Ryan Bixby ... Adam D Norris
    Single-cell splicing of a conserved neuronal kinase is established by a combinatorial code of fate-determining transcription factors and neuronal RNA binding proteins, with different combinations in different neuron types.