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    1. Developmental Biology

    Regulation of X-linked gene expression during early mouse development by Rlim

    Feng Wang et al.
    Single embryo RNA-seq combined with mouse genetics provides a comprehensive view on the roles of Rlim and Xist for the regulation of X-linked gene expression during early mouse embryogenesis.
    1. Evolutionary Biology

    The birth of a bacterial tRNA gene by large-scale, tandem duplication events

    Gökçe B Ayan et al.
    A bacterial tRNA gene set rapidly evolves, compensating the loss of one tRNA type by large duplication events that increase the gene copy number of a second, different tRNA type.
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

    Allen Wang et al.
    Generation of a human lung single nucleus ATAC-seq and single nucleus RNA-seq datasets reveals candidate cis-regulatory elements that advance knowledge on gene expression control in normal and diseased lungs.
    1. Developmental Biology
    2. Neuroscience

    Comprehensive transcriptome analysis of cochlear spiral ganglion neurons at multiple ages

    Chao Li et al.
    RNA-Seq analysis and in vivo validation via genetic approach uncover that Scrt2 and Celf4 are expressed in inner ear auditory neurons throughout development.
    1. Developmental Biology
    2. Neuroscience

    Molecular architecture underlying fluid absorption by the developing inner ear

    Keiji Honda et al.
    Genome-wide RNA-seq analysis of single cells of the developing mouse endolymphatic sac reveals its molecular-cellular architecture and a model for salt and fluid absorption required for acquisition of normal inner ear structure and function.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Chromatin accessibility dynamics and single cell RNA-Seq reveal new regulators of regeneration in neural progenitors

    Anneke Dixie Kakebeen et al.
    Regenerating neural progenitors of the Xenopus tropicalis tail prioritize differentiation to motor neuron types earlier than proliferation, a decision partly regulated by the transcription factors Pbx3 and Meis1.
    1. Cell Biology

    Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

    Adam J Reid et al.
    Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Testis single-cell RNA-seq reveals the dynamics of de novo gene transcription and germline mutational bias in Drosophila

    Evan Witt et al.
    Single-cell RNA-sequencing and germline substitutions provide novel insights into how testis is a hotspot for evolutionary innovation of genes, expression, and mutation at the single-cell level.
    1. Chromosomes and Gene Expression

    Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling

    Jun Yao et al.
    Human plasma contains protein-protected mRNA fragments, myriad repeat RNAs, and novel intron RNAs, including a family of structured full-length excised introns, some corresponding to mirtron pre-miRNAs and agotrons.
    1. Chromosomes and Gene Expression

    Caenorhabditis elegans nuclear RNAi factor SET-32 deposits the transgenerational histone modification, H3K23me3

    Lianna Schwartz-Orbach et al.
    H3K23me3 is a RNAi-mediated transgenerationally heritable heterochromatin mark in Caenorhabditis elegans.