1,144 results found
    1. Cell Biology

    Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility

    Wondwossen M Yeshaw, Marianne van der Zwaag ... Ody CM Sibon
    VPS13A is associated with the endoplasmic reticulum, mitochondria and lipid droplets and is required for cellular processes that require interaction between these organells.
    1. Plant Biology

    Plant Trans-Golgi Network/Early Endosome pH regulation requires Cation Chloride Cotransporter (CCC1)

    Daniel W McKay, Heather E McFarlane ... Stefanie Wege
    Cation chloride cotransporter CCC1 has a central function in plant cells and is the missing ion efflux component of the transport circuit necessary to regulate pH in the lumen of the trans-Golgi-network/early endosome, the major cargo hub in plant cells.
    1. Evolutionary Biology

    Species-specific chromatin landscape determines how transposable elements shape genome evolution

    Yuheng Huang, Harsh Shukla, Yuh Chwen G Lee
    The ultimate driver for the substantial between-species difference in the success of transposable elements, the widely distributed genetic parasite, may lie in the overall chromatin environment.
    1. Computational and Systems Biology
    2. Neuroscience

    Principles for coding associative memories in a compact neural network

    Christian Pritz, Eyal Itskovits ... Alon Zaslaver
    A compact neural network can form various associative memories that are encoded in a distributed manner, where each neuron stores different components of the memory.
    1. Cell Biology
    2. Immunology and Inflammation

    Stable flow-induced expression of KLK10 inhibits endothelial inflammation and atherosclerosis

    Darian Williams, Marwa Mahmoud ... Hanjoong Jo
    KLK10 is a flow-sensitive endothelial protein that serves as an anti-inflammatory, barrier-protective, and anti-atherogenic factor with therapeutic potential.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin

    Ben C Tilly, Gillian E Chalkley ... C Peter Verrijzer
    Visualization of BRM remodelers engaging their endogenous genomic targets revealed highly transient and dynamic interactions with chromatin, which are fueled by ATP-hydrolysis.
    1. Cell Biology
    2. Developmental Biology

    Physically asymmetric division of the C. elegans zygote ensures invariably successful embryogenesis

    Radek Jankele, Rob Jelier, Pierre Gönczy
    Systematic analysis of C. elegans zygotes manipulated to divide equally demonstrates that daughter cell size asymmetry is critical for proper cell cycle timing, positioning, and fates during subsequent embryogenesis.
    1. Cell Biology

    Src activates retrograde membrane traffic through phosphorylation of GBF1

    Joanne Chia, Shyi-Chyi Wang ... Frederic A Bard
    Src phosphorylates GBF1, promoting binding of the Sec7 domain to Arf1 and the formation of GALNTs containing tubules emanating from the Golgi.
    1. Structural Biology and Molecular Biophysics

    Multivalency regulates activity in an intrinsically disordered transcription factor

    Sarah Clark, Janette B Myers ... Elisar J Barbar
    Binding of multiple LC8 copies to the intrinsically disordered region of the transcription factor ASCIZ exemplifies a new and potentially widespread molecular mechanism for negative feedback regulation.
    1. Developmental Biology

    Geometric models for robust encoding of dynamical information into embryonic patterns

    Laurent Jutras-Dubé, Ezzat El-Sherif, Paul François
    Propagation, speed and shapes of genetic waves of expression during development can be modeled by a simple interplay between two transcriptional modules (dynamic/static), which explains robustness and precision of patterning.

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