The protein FRMD8 binds to iRhom and thereby stabilises the iRhom/ADAM17 complex, which is the primary trigger of inflammatory signalling.

In vitro grown human muscle fibers display remarkable self-organisation capacities at the tissue, cellular, and molecular levels that are coordinated by mechanical tension.

Live-cell single-molecule tracking reveals that hierarchical cooperation within the Polycomb Cbx7 protein between the low-affinity H3K27me3-binding module and the high-affinity DNA-binding cassette targets Polycomb repressive complex 1 to chromatin.

MET acts as a dependence receptor in vivo by promoting hepatocyte apoptosis, a response induced by a caspase generated fragment able to favor calcium exchange between endoplasmic reticulum and mitochondria.

VGF was identified as a factor secreted from thalamocortical axons essential for the cytoarchitectonic features of neocortical layer 4 in the sensory areas in mice.

Biased growth of microtubules in the advancing axon tip contributes to the uniform orientation of microtubules in mature axons, which is essential for proper neuronal functioning.

3D niche topology imposes a spatially biased random stem cell loss, which is differentially fine-tuned in neural retina and retinal pigmented epithelium to regulate growth, shape, and cellular topology.

A putative therapeutic target undergoing clinical trials in breast cancer is non-essential and the drug used in those trials blocks cell division through an off-target effect.

A guide summarizing the diversity of cell types in the parabrachial nucleus.

The identification of SMA-miR supports the pathogenic role of skeletal muscle in spinal muscular atrophy and, integrated in the SMA-score, may help to improve the phenotypic prediction for patients.