1,286 results found
    1. Cancer Biology
    Reproducibility Project

    Reproducibility Project: Cancer Biology

    Edited by Roger J Davis et al.
    Investigating reproducibility in preclinical cancer research.
  1. February 2017

    Episode 36: February 2017

    In this episode we hear about epilepsy, the sushi-belt model of transport in neurons, a mother in ancient Troy, the Amazon rainforest and bias in scientific reporting.
  2. Episode 45: February 2018

    In this episode, we hear about disease control in insects, placental development, post-traumatic stress disorder, the mission to create a human cell atlas and how crickets amplify their song.
    1. Physics of Living Systems

    Shared behavioral mechanisms underlie C. elegans aggregation and swarming

    Siyu Serena Ding et al.
    Two seemingly distinct behaviors in social C. elegans worms, namely aggregating into groups and swarming over food, are driven by the same underlying mechanisms.
    1. Computational and Systems Biology
    2. Neuroscience

    Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

    Ryan S Phillips et al.
    Computational modeling motivated by recent experiments clarifies biophysical mechanisms generating the rhythm and amplitude of breathing at the level of neurons and brain circuits in mammals.
    1. Developmental Biology

    A lncRNA fine tunes the dynamics of a cell state transition involving Lin28, let-7 and de novo DNA methylation

    Meng Amy Li et al.
    A novel lncRNA (Ephemeron) is connected to known post-transcriptional and epigenetic regulators as part of an integrated machinery, which controls the timely exit from the naïve state of mouse embryonic stem cells.
    1. Computational and Systems Biology
    2. Developmental Biology

    A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning

    Qixuan Wang et al.
    Regional differences in activator and inhibitor signals alter hair cycle pace across mouse skin and produce unique fur renewal 'landscapes', with fastest renewal on the ventrum and slowest renewal on the ear pinnae.
    1. Developmental Biology

    Revised roles of ISL1 in a hES cell-based model of human heart chamber specification

    Roberto Quaranta et al.
    Loss and gain-of-function investigation uncovers a regulatory network controlling human heart chamber specification in which the cardiac precursor gene ISL1 accelerates ventricular induction and antagonizes retinoic acid-driven atrial commitment.
    1. Cell Biology
    2. Developmental Biology

    Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos

    Matthew Richard Johnson et al.
    In early Drosophila embryos, histone H2Av continuously exchanges between cytoplasmic lipid droplets, a process that modulates H2Av import into nuclei and constitutes a novel post-translational strategy to regulate nuclear H2Av levels.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death

    Laurelle Jackson et al.
    Under conditions where the force of HIV infection per cell is high, partial attenuation of infection with inhibitors can increase the number of live infected cells and may paradoxically be beneficial for viral spread.

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