221 results found
    1. Cell Biology
    2. Developmental Biology and Stem Cells

    R-spondins can potentiate WNT signaling without LGRs

    Andres M Lebensohn, Rajat Rohatgi
    R-spondins 2 and 3 can potentiate WNT signaling in the absence of LGRs through interactions with ZNRF3/RNF43 E3 ubiquitin ligases and heparan sulfate proteoglycans, defining two alternative modes of R-spondin-mediated signaling.
  1. Research: Publication bias and the canonization of false facts

    Silas Boye Nissen et al.
    Publication bias, in which positive results are preferentially reported by authors and published by journals, can restrict the visibility of evidence against false claims and allow such claims to be canonized inappropriately as facts.
    1. Epidemiology and Global Health

    Science Forum: Unit of analysis issues in laboratory-based research

    Nick R Parsons et al.
    A simulation study is used to demonstrate how mistakes in identifying the experimental unit and the unit of analysis can lead to incorrect analyses and inappropriate inferences when reporting research studies.
    1. Ecology
    2. Evolutionary Biology

    Point of View: Towards a mechanistic foundation of evolutionary theory

    Michael Doebeli et al.
    A description of evolution that is based on birth-death processes, and in which fitness is at most a derived quantity, is advocated.
    1. Computational and Systems Biology
    2. Neuroscience

    Fundamental bound on the persistence and capacity of short-term memory stored as graded persistent activity

    Onur Ozan Koyluoglu et al.
    A fundamental lower-bound on memory recall precision, which declines with storage duration and number of stored items, is derived, and human performance is shown to be well-fit by this theoretical bound.
    1. Neuroscience

    Network-wide reorganization of procedural memory during NREM sleep revealed by fMRI

    Shahabeddin Vahdat et al.
    Non-REM sleep is essential in the restoration of initial motor memory trace and gradual reorganization of newly-learned information underlying human procedural memory consolidation.
    1. Neuroscience

    Attenuation of dopamine-modulated prefrontal value signals underlies probabilistic reward learning deficits in old age

    Lieke de Boer et al.
    Attenuated anticipatory activity in ventromedial prefrontal cortex is modulated by dopamine D1 receptor density in nucleus accumbens, and accounts for impaired probabilistic reward learning in older adults.
    1. Neuroscience

    Task-dependent recurrent dynamics in visual cortex

    Satohiro Tajima et al.
    A decoding-based, state-space reconstruction reveals that neurons in macaque IT cortex change the structure of their collective attractor dynamics depending on task contexts.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Physical limits of flow sensing in the left-right organizer

    Rita R Ferreira et al.
    Large-scale in vivo imaging of the zebrafish left-right organizer (Kupffer's vesicle) combined with fluid dynamics calculations allows to quantitatively test the possible flow detection mechanisms and supports the flow transport of chemical signals as the mechanism of side determination.

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