1,733 results found
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li et al.
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Microbiology and Infectious Disease

    Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

    Jennifer L Elliott et al.
    HIV-1 integrase-RNA interactions account for the key role of integrase in particle maturation.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    RNA from a simple-tandem repeat is required for sperm maturation and male fertility in Drosophila melanogaster

    Wilbur Kyle Mills et al.
    Sperm production and male fertility in Drosophila melanogaster depend on transcripts generated from the AAGAG(n) repeated satellite DNA within primary spermatocytes.
    1. Ecology
    2. Neuroscience

    Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase

    Sven Schenk et al.
    A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.
    1. Cell Biology
    2. Developmental Biology

    A transcriptomics resource reveals a transcriptional transition during ordered sarcomere morphogenesis in flight muscle

    Maria L Spletter et al.
    A developmental transcriptomics resource from Drosophila flight muscles quantifies the transcriptional dynamics during muscle morphogenesis and identifies three ordered phases of sarcomere morphogenesis.
    1. Microbiology and Infectious Disease

    Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans

    Linxia Liu et al.
    Meiosis and differentiation of basidium, a defining sexual structure of the phylum Basidiomycota, are genetically integrated by a shared regulatory program to ensure the formation of infectious meiospores in Cryptococcus neoformans.
    1. Computational and Systems Biology
    2. Developmental Biology

    The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium

    Katharina Schlereth et al.
    The acquisition of vascular quiescence during transition to adulthood is driven by distinct transcriptional and epigenetic programs of pro- and anti-angiogenic genes, with the most prominent effect on the suppression of TGFß family signaling.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcriptional adaptation in Caenorhabditis elegans

    Vahan Serobyan et al.
    Genes implicated in mutant mRNA decay and small RNA maturation and transport into the nucleus are required for transcriptional adaptation in C. elegans.
    1. Developmental Biology

    Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

    Maria C Marchetto et al.
    Using iPSCs as a model to study neurodevelopmental differences between human and nonhuman primates lays the groundwork for understanding aspects of human brain evolution and neurological disease susceptibility.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation

    Daniil Alpern et al.
    Physical and functional interactions between HNF4A and TAF4 coordinate HNF4A genomic occupancy with pre-initiation complex formation to activate post-natal hepatocyte gene expression.

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