2,649 results found
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Gene autoregulation by 3’ UTR-derived bacterial small RNAs

    Mona Hoyos et al.
    Bacterial small RNAs derived from the 3' untranslated region of an mRNA can serve as autoregulatory elements.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome

    An Van den Bossche et al.
    A bacteriophage remodels the RNA metabolism machinery of a bacterial host to sequentially clear host transcripts and then stabilize the viral RNA.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dynamic interactions between the RNA chaperone Hfq, small regulatory RNAs, and mRNAs in live bacterial cells

    Seongjin Park et al.
    RNA chaperone Hfq dynamically binds various pools of cellular RNAs to execute different regulatory functions.
    1. Cell Biology

    The transcription factor Hey and nuclear lamins specify and maintain cell identity

    Naama Flint Brodsly et al.
    Hey together with LaminC continuously supervise nuclear organisation and differentiated enterocyte identity, a regulation that is lost upon ageing, resulting in loss of gut homeostasis.
    1. Genetics and Genomics

    Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity

    Prithvi Raj et al.
    Genetic variations that underlie common autoimmune disease genes are predominantly regulatory and modify the expression of multiple genes within the HLA gene complex and throughout the immune system.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes

    Nora Yucel et al.
    Endothelial cells in the heart have transcriptional and epigenetic signatures of cardiomyocytes.
    1. Microbiology and Infectious Disease

    Regulatory roles of Escherichia coli 5' UTR and ORF-internal RNAs detected by 3' end mapping

    Philip P Adams et al.
    Multiple RNA-seq approaches globally mapped RNA 3´ ends resulting in the discovery of numerous and diverse RNA regulators.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Improved CUT&RUN chromatin profiling tools

    Michael P Meers et al.
    Enhancements to the CUT&RUN antibody-targeted nuclease strategy for chromatin profiling include an improved affinity-cleavage fusion protein and digestion protocol, and a simplified calibration strategy.
    1. Stem Cells and Regenerative Medicine

    Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

    Joseph Herdy et al.
    An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
    1. Cancer Biology

    Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

    Zeyad D Nassar et al.
    DECR1, a rate-limiting enzyme for polyunsaturated fatty acid (PUFA) β-oxidation, is an androgen-repressed gene in prostate cancer cells that limits oxidative stress to promote cancer cell survival.

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