5,269 results found
    1. Medicine
    2. Immunology and Inflammation

    Concerted changes in the pediatric single-cell intestinal ecosystem before and after anti-TNF blockade

    Hengqi Betty Zheng, Benjamin A. Doran ... Leslie S. Kean
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

    Ulrike Künzel, Adam Graham Grieve ... Matthew Freeman
    The protein FRMD8 binds to iRhom and thereby stabilises the iRhom/ADAM17 complex, which is the primary trigger of inflammatory signalling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    FRET-based dynamic structural biology: Challenges, perspectives and an appeal for open-science practices

    Eitan Lerner, Anders Barth ... Shimon Weiss
    A summary of the current “state-of-the-field” of single-molecule FRET used for probing biomolecular structural dynamics.
    1. Biochemistry and Chemical Biology

    Nuclear bodies protect phase separated proteins from degradation in stressed proteome

    Kwan Ho Jung, Jiarui Sun ... Xin Zhang
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Evidence for DNA-mediated nuclear compartmentalization distinct from phase separation

    David Trombley McSwiggen, Anders S Hansen ... Xavier Darzacq
    Transient DNA interactions by DNA-binding proteins are utilized by herpes simple virus as an alternative route to generate membraneless compartments in the nucleus without invoking phase separation.
    1. Cancer Biology
    2. Immunology and Inflammation

    Cancer systems immunology

    Nathan E Reticker-Flynn, Edgar G Engleman
    Cancer systems immunology is a highly interdisciplinary field that is advancing our ability to understand and predict the complex behavior that orchestrates the interplay between tumors and the immune system.
    1. Cell Biology

    Stratification of enterochromaffin cells by single-cell expression analysis

    Yan Song, Linda J. Fothergill ... Gene W. Yeo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Role of the postinspiratory complex in regulating swallow–breathing coordination and other laryngeal behaviors

    Alyssa Huff, Marlusa Karlen-Amarante ... Jan-Marino Ramirez
    The postinspiratory complex acts as an interface between the swallow pattern generator and the preBötzinger complex to coordinate swallow and breathing.

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