1,922 results found
    1. Structural Biology and Molecular Biophysics

    Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site

    Celso M Teixeira-Duarte et al.
    Cations are essential cofactors in the ATP activation mechanism of the KtrAB cation channel and appear to be cofactors of many other nucleotide-dependent RCK domains.
    1. Developmental Biology
    2. Neuroscience

    Molecular determinants in Frizzled, Reck, and Wnt7a for ligand-specific signaling in neurovascular development

    Chris Cho et al.
    Molecular dissection of Frizzled, Reck, and Wnt7a provides critical insight into the long-standing question of ligand-receptor specificity in the field of Wnt signaling.
    1. Cancer Biology
    2. Cell Biology

    Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis

    Sandra Kümper et al.
    The Rho kinases ROCK1 and 2 act redundantly in regulating cell proliferation and their depletion causes cellular senescence.
    1. Developmental Biology

    Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis

    Benoit Vanhollebeke et al.
    The membrane proteins Reck and Gpr124 are integral components of a novel Wnt7a/Wnt7b-specific signaling complex, and there is a distinctive requirement for Wnt/β-catenin signaling in tip cells during angiogenesis in the central nervous system.
    1. Cancer Biology
    2. Cell Biology

    Cell Proliferation: The ROCKs on which tumour cells thrive

    Simon Wilkinson, Margaret C Frame
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    1. Structural Biology and Molecular Biophysics

    Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism

    Jingjing Guo, Huan-Xiang Zhou
    Simulations of molecular dynamics suggest how the binding of the β-grasp domain of SUMO1 induces conformational and dynamic effects to activate SENP1.
    1. Stem Cells and Regenerative Medicine

    Stem Cells: What silent mutations say about the human airways

    Matthew L Donne, Jason R Rock
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    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    IP3 mediated global Ca2+ signals arise through two temporally and spatially distinct modes of Ca2+ release

    Jeffrey T Lock, Ian Parker
    Cell-wide Ca2+ signals that regulate numerous cellular functions comprise dual Ca2+ release modes through IP3 receptors, punctate transients mediated by clustered receptors and spatiotemporally diffuse release through functionally distinct receptors.
    1. Neuroscience

    An inhibitory corticostriatal pathway

    Crystal Rock et al.
    The discovery of somatostatin-positive inhibitory neurons projecting from mouse cortex to striatum shows that corticostriatal pathways are not exclusively excitatory.

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