Franziska Bleichert, Maxim Balasov ... James M Berger
Electron microscopy uncovers the structure of the origin recognition complex (ORC) in metazoans, and reveals how mutations in the ORC6 subunit lead to Meier-Gorlin syndrome in humans.
Megumi Hatori, Shubhroz Gill ... Satchidananda Panda
A transcription factor called Lhx1 coordinates the activity of the brain's master circadian clock, the suprachiasmatic nucleus, by controlling communication between its constituent cells.
Rory P Wilson, Iwan W Griffiths ... David M Scantlebury
Increased mass enhances speed but compromises turning capacity in pursuit predators; this has widespread ramifications for the best strategies for predators and prey during chases according to their relative masses.
The origin recognition complex is a dynamic complex that assumes various conformational states that likely correspond to different steps in replication initiation.
A muscle-derived Wnt signal promotes dendritic branching of somatosensory neurons in response to a concurrent deficiency in vitamins, minerals, and cholesterol.
Alexandre P Thiery, Ariane SI Standing ... Gareth J Fraser
The development of diverse tooth shapes among vertebrates, from sharks to mammals, is a highly conserved process, utilising a similar dental signalling centre for more than 400 million years.
Mark A McClintock, Carly I Dix ... Simon L Bullock
Reconstitution of dynein-based mRNA transport with purified components reveals a pivotal role of an RNA localisation signal in controlling the assembly and activity of the translocation machinery.
As a cell prepares to divide, a molecular actor known as the Origin Recognition Complex makes intricate ATP-driven movements to recruit proteins required to duplicate DNA.
