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    1. Neuroscience

    A robust activity marking system for exploring active neuronal ensembles

    Andreas T Sørensen et al.
    A new system for tagging activated neuronal population offers multiple advantages over existing systems based on immediate early genes, including greater sensitivity and specificity, and suitability for easy application in species other than mice.
    1. Neuroscience

    CCR5 is a suppressor for cortical plasticity and hippocampal learning and memory

    Miou Zhou et al.
    Repression of the G protein-coupled chemokine receptor CCR5 enhances MAPK/CREB signaling, long-term potentiation, somatosensory cortical plasticity, and learning and memory, while CCR5 over-activation by viral proteins may contribute to HIV-associated cognitive deficits.
    1. Neuroscience

    Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

    Margarita C Dinamarca et al.
    A protein called RNF10 relays messages from synapses to neuron cell nuclei, and is responsible for long-lasting modifications of dendritic spines as observed after activation of synaptic glutamate receptors.
    1. Cell Biology
    2. Genomics and Evolutionary Biology

    KPNB1 mediates PER/CRY nuclear translocation and circadian clock function

    Yool Lee et al.
    KPNB1 regulates rhythmic spatio-temporal nuclear import of the PER/CRY complex and is required for negative feedback repression in mammalian and fly clock function.
    1. Cell Biology
    2. Plant Biology

    SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

    Andrea Mair et al.
    The transcription factor bZIP63 is a key regulator of the starvation response in the model plant Arabidopsis thaliana and is directly targeted by the kinase SnRK1.
    1. Neuroscience

    Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia

    Shanping Chen et al.
    Storage of long-term memory in Aplysia does not require stable synapses.
    1. Cell Biology

    Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution

    Jennifer L Mamrosh et al.
    LRH-1/NR5A2 responds to ER stress by inducing a novel pathway that is required for stress resolution in mice and can be targeted by LRH-1 agonists.
    1. Neuroscience

    Enhancement of fear memory by retrieval through reconsolidation

    Hotaka Fukushima et al.
    Retrieval enhances fear memory through reconsolidation by activating calcineurin-induced protein degradation and CREB-mediated gene expression in amygdala, hippocampus, and mPFC.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    MOF-associated complexes ensure stem cell identity and Xist repression

    Tomasz Chelmicki et al.
    Two complexes that contain the histone acetyl transferase MOF engage in a two-pronged approach to ensure the repression of X inactivation in mouse embryonic stem cells.
    1. Neuroscience

    A longitudinal study of Caenorhabditis elegans larvae reveals a novel locomotion switch, regulated by Gαs signaling

    Stanislav Nagy et al.
    C. elegans exhibits two distinct behavioural macro-states, active and quiet wakefulness, and protein kinase A regulates switching between these two states.