4,515 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs

    Michelle S Reid, David M Kern, Stephen Graf Brohawn
    The structure of the potassium-chloride cotransporter KCC4 provides insight into the basis of ion specificity, transport stoichiometry, and activity regulation for a broadly physiologically and clinically important transporter family.
    1. Neuroscience

    Learning place cells, grid cells and invariances with excitatory and inhibitory plasticity

    Simon Nikolaus Weber, Henning Sprekeler
    A large variety of spatial representations implied in rodent navigation could arise robustly and rapidly from inputs with a weak spatial structure, by an interaction of excitatory and inhibitory synaptic plasticity.
    1. Neuroscience

    During hippocampal inactivation, grid cells maintain synchrony, even when the grid pattern is lost

    Noam Almog, Gilad Tocker ... Dori Derdikman
    Grid cells lose their hexagonality during hippocampal inactivation, but maintain temporal and spatial synchrony between pairs of cells, implying that hippocampus does not determine phase relations between grid cells.
    1. Neuroscience

    Impaired speed encoding and grid cell periodicity in a mouse model of tauopathy

    Thomas Ridler, Jonathan Witton ... Jonathan T Brown
    Dementia-related tau pathology reduces speed encoding in the medial entorhinal cortex and is associated with reduced grid cell function, whilst head direction tuning remains intact.
    1. Neuroscience

    Task-anchored grid cell firing is selectively associated with successful path integration-dependent behaviour

    Harry Clark, Matthew F Nolan
    Anchoring of grid firing fields to task environments is consistent with roles specifically in path integration rather than spatial localisation in general.
    1. Neuroscience

    A principle of economy predicts the functional architecture of grid cells

    Xue-Xin Wei, Jason Prentice, Vijay Balasubramanian
    Mathematical modeling suggests that grid cells in the rodent brain use fundamental principles of number theory to maximize the efficiency of spatial mapping, enabling animals to accurately encode their location with as few neurons as possible.
    1. Cell Biology

    Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

    Adam J Reid, Arthur M Talman ... Mara KN Lawniczak
    Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.
    1. Computational and Systems Biology

    Meta-Research: Incidences of problematic cell lines are lower in papers that use RRIDs to identify cell lines

    Zeljana Babic, Amanda Capes-Davis ... Anita E Bandrowski
    The use of Research Resource Identifiers (RRIDs) improves the proper use of cell lines in the biomedical literature.
    1. Neuroscience
    2. Physics of Living Systems

    A geometric attractor mechanism for self-organization of entorhinal grid modules

    Louis Kang, Vijay Balasubramanian
    The hierarchy of entorhinal grid cell modules with constant scale ratios can self-organize through a new geometrically organized attractor mechanism.
    1. Neuroscience

    Visual landmarks sharpen grid cell metric and confer context specificity to neurons of the medial entorhinal cortex

    José Antonio Pérez-Escobar, Olga Kornienko ... Kevin Allen
    The firing rate of MEC neurons conveys information about visual landmarks.

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