Loss of RUNX1, a key regulator of estrogen receptor-positive luminal breast cells, impairs mammary epithelial differentiation and contributes to luminal breast cancer via genetic interactions with a loss of p53 or RB1.

The transcription factor RUNX1 marks a distinct lineage of luminal castration-resistant prostate cells established early during development and enriched in the periurethral region of adult mouse prostate.

Noradrenaline-mediated astrocytic Ca²⁺ signaling in behavior is reduced in awake-behaving tg-ArcSwe Alzheimer's disease transgenic mice.

Natural step-to-step variations show how human running is stabilized, underscoring the importance of center of mass control and showing how humans run without falling despite muscle noise and uneven terrain.

RUNX2 plays an important role in human NK cell biology by driving differentiation, inhibiting cytokine production, and inducing a tissue-resident phenotype, which has implications for improving NK cell therapy for cancer patients.

Neuronal participation in generation of motor patterns in the spinal circuits is lognormal, which is an indication of a rich diversity of activity within the mean-driven as well as the fluctuation-driven regimes.

The extrinsic cue NGF and the intrinsic signal Islet1 converge at the level of the Runx1/CBFβ transcription factor complex formation to promote differentiation of a major nociceptor subtype.

Enhancements to the CUT&RUN antibody-targeted nuclease strategy for chromatin profiling include an improved affinity-cleavage fusion protein and digestion protocol, and a simplified calibration strategy.

Despite size heterogeneity, an epitope-resurfaced mature-form dengue VLP has the potential to induce quaternary structure-recognizing broad cross-reactive neutralizing antibodies.

CUT&RUN (Cleavage Under Targets & Release Using Nuclease) profiles antibody-targeted DNA-binding proteins in situ with high resolution and low background, providing a simple, robust and scalable alternative to chromatin immunoprecipitation.