263 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Integration of ATAC and RNA-sequencing identifies chromatin and transcriptomic signatures in classical and non-classical zebrafish osteoblasts and indicates mechanisms of entpd5a regulation

    Kleio Petratou, Martin Stehling ... Stefan Schulte-Merker
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Compelling
    • Convincing
    1. Stem Cells and Regenerative Medicine

    Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

    Sujeethkumar Prithiviraj, Alejandro Garcia Garcia ... Paul E Bourgine
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology

    Single-nucleus multiomics reveals the gene-regulatory networks underlying sex determination of murine primordial germ cells

    Adriana K Alexander, Karina F Rodriguez ... Humphrey Hung-Chang Yao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility

    Sophie Debaenst, Tamara Jarayseh ... Andy Willaert
    Crispant analysis in zebrafish serves as a powerful tool for the rapid functional screening of genes implicated in bone fragility disorders, like osteogenesis imperfecta and osteoporosis.
    1. Developmental Biology
    2. Genetics and Genomics

    Determining the effects of paternal obesity on sperm chromatin at histone H3 lysine 4 tri-methylation in relation to the placental transcriptome and cellular composition

    Anne-Sophie Pepin, Patrycja A Jazwiec ... Sarah Kimmins
    Epigenomic and transcriptomic analysis reveals that paternal obesity influences sperm histone H3 lysine 4 tri-methylation enrichment and placenta gene expression, which in turn negatively impact its development and function in a manner that may contribute to metabolic disease in offspring.
    1. Cell Biology
    2. Neuroscience

    Psychological stress disturbs bone metabolism via miR-335-3p/Fos signaling in osteoclast

    Jiayao Zhang, Juan Li ... Weicai Liu
    miR-335-3p, which targets FOS and inhibits its activation of NFATC1 signaling, is an important regulator for osteoclast function and responsible for the psychological stress-induced osteoporosis.
    1. Developmental Biology
    2. Genetics and Genomics

    Gene regulatory dynamics during craniofacial development in a carnivorous marsupial

    Laura E Cook, Charles Y Feigin ... Irene Gallego Romero
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics

    DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome

    Hilda Tateossian, Amy Southern ... Steve DM Brown
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Cancer Biology

    The context-dependent epigenetic and organogenesis programs determine 3D vs. 2D cellular fitness of MYC-driven murine liver cancer cells

    Jie Fang, Shivendra Singh ... Jun Yang
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete
    1. Developmental Biology

    NR2F2 is required in the embryonic testis for Fetal Leydig Cell development

    Aitana Perea-Gomez, Natividad Bellido-Carreras ... Marie-Christine Chaboissier
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
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