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    1. Physics of Living Systems
    2. Evolutionary Biology

    Magnetotactic Bacteria Optimally Navigate Natural Pore Networks

    Alexander P Petroff, Vladislav Kelin, Nina Radchenko-Hannafin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    CryoEM structures of Kv1.2 potassium channels, conducting and non-conducting

    Yangyu Wu, Yangyang Yan ... Fred J Sigworth
    The well-studied Kv1.2 potassium ion channel is observed in a variety of states and conditions, to understand mechanisms of ion permeation, gating and block.
    1. Structural Biology and Molecular Biophysics

    Mechanism of dimer selectivity and binding cooperativity of BRAF inhibitors

    Joseph Clayton, Aarion Romany ... Jana Shen
    BRAF inhibitors achieve monomer or dimer selectivity through their ability to modulate dimerization and allosteric communication.
    1. Neuroscience

    Stereotype of mouse social competency and status revealed by a novel competition paradigm in combination with available paradigms

    Meiqiu Liu, Yue Chen, Rongqing Chen
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    • Incomplete
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Synthetic gene circuits that selectively target RAS-driven cancers

    Gabriel Senn, Leon Nissen, Yaakov Benenson
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations

    Gabriel Monteiro da Silva, Kyle Lam ... Brenda M Rubenstein
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Neuroscience

    Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock

    Andrea Brenna, Micaela Borsa ... Urs Albrecht
    The light-modulated protein kinase CDK5 is important for phase shifts of the circadian clock, impacting phase delays through calcium influx and signaling pathways, crucial for adapting to jet lag.
    1. Cell Biology

    Ezrin defines TSC complex activation at endosomal compartments through EGFR–AKT signaling

    Giuliana Giamundo, Daniela Intartaglia ... Ivan Conte
    Ezrin controls endo-lysosomal signaling by maintaining TSC inhibition through EGFR signaling, activating mTORC1, and inhibiting lysosomal function, unveiling a critical endosome–lysosome network essential for autophagy and cellular homeostasis.
    1. Stem Cells and Regenerative Medicine

    Identification of a sub-population of synovial mesenchymal stem cells with enhanced treatment efficacy in a rat model of Osteoarthritis

    Nedaa Al-Jezani, Asmaa Affan ... Roman J Krawetz
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Neuroscience

    GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine

    Takashi Yamamoto, Kayoko Ueji ... Shinya Ugawa
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
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