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    1. Cell Biology

    SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes

    James P Zewe, Rachel C Wills ... Gerald RV Hammond
    SAC1 is unable to adopt an efficient "trans" mode of action in living cells.
    1. Neuroscience

    PBN-PVT projections modulate negative affective states in mice

    Ya-Bing Zhu, Yan Wang ... Di Mu
    The parabrachial nucleus-thalamic paraventricular nucleus pathway is critical for modulating affective states in mice.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A rat epigenetic clock recapitulates phenotypic aging and co-localizes with heterochromatin

    Morgan Levine, Ross A McDevitt ... Luigi Ferrucci
    The first epigenetic clock for rats was developed and revealed to reflect phenotypic aging and captured the effects of longevity interventions.
    1. Neuroscience

    Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity

    Tianyu Tang, Timothy A Blenkinsop, Eric J Lang
    The importance of synchronous Purkinje cell complex spikes for controlling cerebellar output was investigated by simultaneously recording from cerebellar nuclear cells and arrays of Purkinje cells that synapse onto them.
    1. Neuroscience

    Rat sensitivity to multipoint statistics is predicted by efficient coding of natural scenes

    Riccardo Caramellino, Eugenio Piasini ... Davide Zoccolan
    Visual sensitivity to correlation patterns in rats matches that previously measured in humans, as well as predictions from efficient coding theory based on the statistics of natural images.
    1. Neuroscience

    Conditional deletion of glucocorticoid receptors in rat brain results in sex-specific deficits in fear and coping behaviors

    Jessie R Scheimann, Rachel D Moloney ... James P Herman
    Development of a conditional glucocorticoid receptor knockdown rat model allows for high resolution anatomical, physiological and behavioral exploration into the role of glucocorticoid receptor signaling in defined cell populations.
    1. Cancer Biology
    2. Immunology and Inflammation

    The newly-arisen Devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

    Alison Caldwell, Rachel Coleby ... Hannah VT Siddle
    A recently discovered contagious cancer in the Tasmanian devil has the potential to become widespread in the population due to the loss of histocompatibility antigens that are allogeneic to its hosts.
    1. Genetics and Genomics

    Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

    Angela Schulz, Nicola Victoria Müller ... Reinhold Kreutz
    Genetic and functional studies reveal a previously unrecognized role for a transmembrane protein in glomerular filtration barrier function.
    1. Developmental Biology
    2. Neuroscience

    Retrograde Ret signaling controls sensory pioneer axon outgrowth

    Adam Tuttle, Catherine M Drerup ... Alex V Nechiporuk
    Long-range Ret receptor signaling promotes axon outgrowth and regulates growth cone dynamics in pioneer neurons by inducing transcriptional changes in Myosin-X expression.
    1. Neuroscience

    Vocalization–whisking coordination and multisensory integration of social signals in rat auditory cortex

    Rajnish P Rao, Falk Mielke ... Michael Brecht
    Snout-to-snout contact modulates the response of rat auditory cortex to calls from other animals, indicating that the multisensory nature of social interaction is directly represented in the rat brain.