The Parkinson’s protein Leucine-Rich Repeat Kinase 2 contains a GTPase as well as kinase domain and modulates its intrinsic GTPase activity by autophosphorylation of the P-loop residue threonine 1343.

Stress-regulated secretion of an intestinal peptide positively regulates the antioxidant response by promoting neuropeptide release from the nervous system, defining a gut-to-brain-to-gut endocrine axis in the oxidative stress response.

Gradual downregulation of each of the subunits of the evolutionary-conserved exocyst holocomplex shows that the complex is required for biogenesis, maturation, and exocytosis of secretory granules in Drosophila salivary glands.

The USP-50/USP8 protease removes the Rab5 GEF Rabex5 from endosomes while facilitating recruitment of the Rab7 GEF SAND-1/Mon1, promoting endosome maturation.

Actin and the class I myosin TbMyo1 are required to maintain endosomal morphology in the protist parasite Trypanosome brucei.

Unconventional secretion of a plasma membrane purine transporter via Golgi-bypass is established at an early ER-associated secretory compartment revealing that specific cargoes define alternative trafficking routes.