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    1. Cell Biology

    A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics

    Etai Sapoznik et al.
    A novel single-objective light-sheet microscope with unparalleled spatiotemporal resolution enables imaging and optical manipulation of diverse biological specimens and processes.
    1. Cell Biology
    2. Neuroscience

    Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle

    Yunsheng Cheng et al.
    Experiments in C. elegans reveal how synaptotagmin and Rab3, the 'yin and yang' of synapses, control whether transmitter vesicles remain docked at the presynaptic membrane or release their contents into the synapse.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

    Maja Šolman et al.
    Rare mutations in the switch III region of Ras can increase its nanoscale clustering, which enhances effector recruitment and downstream signaling.
    1. Cell Biology

    RalB directly triggers invasion downstream Ras by mobilizing the Wave complex

    Giulia Zago et al.
    By moving from correlations to causality in cancer signal transduction using optogenetics, the sufficiency of RalB activation to trigger invasion and the underlying molecular mechanisms were established.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

    Lars Langemeyer et al.
    Analysis of multiple guanine exchange factors shows that Rab activation can occur via a number of mechanistically distinct GDP-release pathways.
    1. Neuroscience

    Texture coarseness responsive neurons and their mapping in layer 2–3 of the rat barrel cortex in vivo

    Liora Garion et al.
    Neurons within rat somatosensory cortex are selective to texture and are spatially organized according to their texture preference.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

    Martin Steger et al.
    Discovery of a physiological LRRK2 substrate and a new mechanism of Rab regulation should aid Parkinson’s research and the understanding of Rab function.
    1. Cell Biology

    Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

    Koji Yamano et al.
    Two GAP proteins bound to mitochondria regulate the enyzme Rab7, and thereby the expansion of the isolation membrane during mitophagy, downstream of PINK1 and Parkin, two proteins that are mutated in familial Parkinson's disease.
    1. Cell Biology
    2. Plant Biology

    Integration of two RAB5 groups during endosomal transport in plants

    Emi Ito et al.
    Plant-unique RAB5 effector 2 (PUF2) is an effector of plant-unique ARA6, which plays a key role in plant endosomal transport, integrating functions of the two plant RAB5 groups by an unprecedented mechanism.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution

    Scott M Coyle, Wendell A Lim
    A systems level reconstitution of H-Ras GTPase signaling reveals a rich space of tunable dynamic outputs and clarifies the consequences of oncogenic perturbations to signaling.