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    1. Cell Biology
    2. Developmental Biology

    Protein phosphatase 1 activity controls a balance between collective and single cell modes of migration

    Yujun Chen, Nirupama Kotian ... Jocelyn A McDonald
    Protein phosphatase 1 activity promotes cohesive collective cell migration by restricting actomyosin contractility to the periphery of the collective and maintaining proper cadherin–catenin complex protein levels at cell–cell junctions.
    1. Cell Biology
    2. Developmental Biology

    Proliferation-independent regulation of organ size by Fgf/Notch signaling

    Agnė Kozlovskaja-Gumbrienė, Ren Yi ... Tatjana Piotrowski
    Cell adhesion regulates organ size in the zebrafish lateral line system.
    1. Neuroscience

    Axonal injury signaling is restrained by a spared synaptic branch

    Laura J Smithson, Juliana Zang ... Catherine A Collins
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology
    2. Computational and Systems Biology

    Single-cell transcriptomics identifies Keap1-Nrf2 regulated collective invasion in a Drosophila tumor model

    Deeptiman Chatterjee, Caique Almeida Machado Costa ... Wu-Min Deng
    Comprehensive transcriptomic analyses describe the underlying tumorigenic gene expression state in the invasive Drosophila follicle cells following the loss of epithelial cell polarity and identify a non-canonical role of Keap1-Nrf2 signaling in regulating collective cell invasion.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

    Jie Luo, Jeff Ranish
    A novel pair of isobaric crosslinking reagents is described, which allow relative quantification of crosslinker-modified peptides during mass spectrometry analysis for comparative structural studies of proteins and protein complexes.
    1. Cell Biology

    High-resolution secretory timeline from vesicle formation at the Golgi to fusion at the plasma membrane in S. cerevisiae

    Robert M Gingras, Abigail M Sulpizio ... Anthony Bretscher
    The first quantitative live-cell microscopy this work shows depicting the order of events preceding secretion in budding yeast.
    1. Plant Biology

    An oomycete effector subverts host vesicle trafficking to channel starvation-induced autophagy to the pathogen interface

    Pooja Pandey, Alexandre Y Leary ... Tolga O Bozkurt
    A pathogen effector mimics starvation-induced autophagy by subverting host endomembrane trafficking to stimulate biogenesis of autophagosomes around pathogen feeding sites, revealing how pathogens interlock distinct host compartments to facilitate infection.
    1. Neuroscience

    Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition

    Vivek Mahadevan, C Sahara Khademullah ... Melanie A Woodin
    Unbiased functional proteomics reveal that protein interactions are a key regulator of the strength of synaptic inhibition in neurons of the central nervous system.
    1. Immunology and Inflammation

    A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice

    Fei Tang, Peng Zhang ... Pan Zheng
    A novel population of hematopoietic cells unmasked by mTORC1 inactivation reveals a new mechanism of innate immune tolerance and a new consequence of defective hematopoiesis.
    1. Neuroscience

    Systematic morphological and morphometric analysis of identified olfactory receptor neurons in Drosophila melanogaster

    Cesar Nava Gonzales, Quintyn McKaughan ... Chih-Ying Su
    A morphological characterization of Drosophila olfactory receptor neurons—conducted systematically at nanoscale resolution—yields an extensive morphometric dataset, identifies novel features of olfactory sensilla, and raises intriguing questions for how the size and shape of sensory neurons influence their function.