4,029 results found
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Cis-regulatory evolution integrated the Bric-à-brac transcription factors into a novel fruit fly gene regulatory network

    Maxwell J Roeske et al.
    The conserved biochemical activity of the duplicate Bab transcription factors were integrated into the regulatory hierarchy of an evolving gene regulatory network by binding site gains in a target gene's cis-regulatory region.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells

    Paula Freire-Pritchett et al.
    Promoter interactome maps in human embryonic stem cells (ESCs) and ESC-derived early neuroectodermal progenitors link distal enhancers to putative target genes, reveal lineage-specific cis-regulatory architecture and shed light on the logic of gene regulation by multiple enhancers.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

    Axelle Marchant et al.
    Regulatory evolution allows paralogs to escape from strucural pleiotropy.
    1. Computational and Systems Biology
    2. Developmental Biology

    Odd-paired controls frequency doubling in Drosophila segmentation by altering the pair-rule gene regulatory network

    Erik Clark, Michael Akam
    The organisation of the Drosophila embryo into segmental units is orchestrated by combinatorial regulatory interactions between spatially patterned and temporally patterned transcription factors.
    1. Computational and Systems Biology

    Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments

    Christopher A Jackson et al.
    Single cell expression data can be used to determine how regulatory transcription factors and target genes are connected, and is especially useful when studying transcription factors controlling heterogeneous cell states.
    1. Developmental Biology

    Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

    Carine Gubelmann et al.
    A large-scale transcription factor screen reveals over twenty novel adipogenic regulators: most notably ZEB1, which exerts essential transcriptional control of fat cell differentiation.
    1. Genetics and Genomics

    Gene regulatory network plasticity predates a switch in function of a conserved transcription regulator

    Isabel Nocedal et al.
    Rapid evolutionary rewiring of the meiosis transcription network facilitated a switch in the function of a master regulator from regulating meiosis to regulating biofilm formation.
    1. Developmental Biology
    2. Evolutionary Biology

    Logics and properties of a genetic regulatory program that drives embryonic muscle development in an echinoderm

    Carmen Andrikou et al.
    A gene regulatory network model provides a simplified explanation of the molecular interactions that orchestrate muscle development in the sea urchin embryo.
    1. Microbiology and Infectious Disease

    The horizontally-acquired response regulator SsrB drives a Salmonella lifestyle switch by relieving biofilm silencing

    Stuti K Desai et al.
    A response regulator acquired via lateral gene transfer has rewired an ancestral genetic circuitry and regulates alternative pathogenic lifestyles.
    1. Genetics and Genomics

    Non-allelic gene conversion enables rapid evolutionary change at multiple regulatory sites encoded by transposable elements

    Christopher E Ellison, Doris Bachtrog
    Fully functional regulatory elements can arise rapidly from transposable elements via a novel route where non-allelic gene conversion can act to speed up the evolutionary fine-tuning of regulatory elements.

Refine your results by:

Type
Research categories