The RNA binding protein PTBP1 controls an extensive program of alternative splicing in embryonic stem cells, one function of which is to repress neuronal transcriptional programs.

Condensation of cytosolic protein YBX1 into processing bodies reveals mechanisms for efficient and selective sorting of proteins and their cognate microRNAs into exosomes.

P-Rex1 adopts an inactive, compact conformation that is stabilized by an abundant intracellular molecule and undergoes dynamic changes to extend upon encountering signaling phospholipids in membranes.

Regulation of conserved Nodal factors by a maternal protein ensures that Nodal signaling is repressed until the appropriate time in embryonic development.

Laser-ablating neurons of a single genetic class reveals that Dbx1-derived interneurons comprise core respiratory rhythmogenic and premotor circuits and provides quantitative cellular parameters that govern network functionality

A cell-free reaction that reconstitutes the selective sorting of a miRNA into exosomes reveals an RNA-binding protein, YBX1, as a critical sorting factor.

The development of an integrative computational-experimental approach for identifying small molecules that can disrupt RNA:protein interactions in vitro and in cells led to the identification of several inhibitors of YBX1 in the micromolar range, including a previously approved drug.

Building on previous work (Wang et al., 2014), we use a combination of genetic, electrophysiology and laser ablation approaches to identify a developmentally defined population of neurons that are a significant source of clinically relevant inspiratory drive to XII motoneurons.

The rhythmic patterns of activity that underlie breathing are generated and coordinated by distinct populations of neurons within the brainstem.

Cyclin D1 protein stability is regulated by ubiquitin-proteasome mechanism mediated by multiple E3 ligases, including newly identified Keap1, DDB2, and WSB2.