275 results found
    1. Structural Biology and Molecular Biophysics

    The crystal structure of bromide-bound GtACR1 reveals a pre-activated state in the transmembrane anion tunnel

    Hai Li et al.
    Substrate-induced structural changes in GtACR1 provide new insight into the chemical mechanism of natural light-gated anion conductance and facilitate its optimization for photoinhibition of neuron firing in optogenetics.
    1. Neuroscience

    Adapting non-invasive human recordings along multiple task-axes shows unfolding of spontaneous and over-trained choice

    Yu Takagi et al.
    Adaptation along multiple task-axes reveals choice traces at millisecond resolution in non-invasive recordings from human premotor cortex and provides evidence that theories of top-down control hold even after extensive experience.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

    Jenny I Aguilar et al.
    A dopamine transporter deficiency syndrome (DTDS)-linked mutation, R445C, underlies dopamine dysfunction and, more broadly, the clinical phenotypes shared by DTDS and Parkinson’s disease.
    1. Computational and Systems Biology
    2. Neuroscience

    Trading mental effort for confidence in the metacognitive control of value-based decision-making

    Douglas G Lee, Jean Daunizeau
    Intra-individual variability in choice, response time, subjective effort, confidence, and choice-induced preference change and certainty gain is explained by a cost–benefit model of cognitive resource allocation.
    1. Biochemistry and Chemical Biology

    De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

    Erich Stefan et al.
    By random nonstandard peptide integrated discovery, combinatorial macrocyclic peptides were leavaged that target a heterodimeric ABC transport complex and explore fundamental principles of the substrate translocation cycle.
    1. Neuroscience

    Multiple decisions about one object involve parallel sensory acquisition but time-multiplexed evidence incorporation

    Yul HR Kang et al.
    When making two decisions about one object, two streams of information can be acquired in parallel but must be incorporated into the two decisions serially, consistent with a central bottleneck.
    1. Cell Biology
    2. Neuroscience

    The role of sigma 1 receptor in organization of endoplasmic reticulum signaling microdomains

    Vladimir Zhemkov et al.
    Signaling function of sigma 1 receptor is related to its ability to organize cholesterol-enriched microdomains in the endoplasmic reticulum membrane.
    1. Biochemistry and Chemical Biology

    In vitro reconstitution reveals major differences between human and bacterial cytochrome c synthases

    Molly C Sutherland et al.
    Despite the known heme attachment motif (CXXCH) in all c-type cytochromes, attachment elements recognized by human and bacterial cytochrome c biogenesis pathways are distinct, providing clear targets for differential inhibitors.
    1. Neuroscience

    Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience

    Alexander Fengler et al.
    A novel method and software provides researchers with the capability to rapidly, flexibly, and robustly perform Bayesian parameter estimation of theoretically meaningful models in cognitive neuroscience that were heretofore intractable.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies

    Christophe Caillat et al.
    The structure of gp41with its membrane anchors highlights the flexible linkage of the transmembrane regions and the fuson peptides, which generates an asymmetric conformation, a potential target of MPER bNAbs.

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