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    1. Neuroscience

    Perceptual decisions are biased by the cost to act

    Nobuhiro Hagura et al.
    When choosing between stimuli, the effort required to act on the resulting decision influences the processing of the stimuli themselves.
    1. Neuroscience

    Integrative and distinctive coding of visual and conceptual object features in the ventral visual stream

    Chris B Martin et al.
    Perirhinal cortex, a brain structure located in the medial temporal lobe, uniquely supports the integration of visual and conceptual object information.
    1. Biochemistry and Chemical Biology

    De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

    Erich Stefan et al.
    By random nonstandard peptide integrated discovery, combinatorial macrocyclic peptides were leavaged that target a heterodimeric ABC transport complex and explore fundamental principles of the substrate translocation cycle.
    1. Neuroscience

    Preserved sensory processing but hampered conflict detection when stimulus input is task-irrelevant

    Stijn Adriaan Nuiten et al.
    When all features of conflicting sensory input are task-irrelevant, the brain can still process its sensory information, whereas conflict detection requires that minimally one stimulus feature is task-relevant or associated with a response.
    1. Neuroscience

    Frontal eye field and caudate neurons make different contributions to reward-biased perceptual decisions

    Yunshu Fan et al.
    In monkeys making decisions that balance noisy evidence and reward expectation, frontal cortical and caudate activity reflect different computational components that are related to the monkeys' strategy.
    1. Structural Biology and Molecular Biophysics

    Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter

    Julia Steiner, Leonid Sazanov
    Structure of the Mrp antiporter, an ancestor of respiratory complex I, suggests a mechanism of coupling between cation and proton translocation, applicable to a large family of related membrane proteins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Chemical and structural investigation of the paroxetine-human serotonin transporter complex

    Jonathan A Coleman et al.
    Structural and biochemical analysis of the mechanism of paroxetine binding to the serotonin transporter provides a framework for transporter inhibition and design of small-molecule inhibitors.
    1. Neuroscience

    Neural dynamics of visual ambiguity resolution by perceptual prior

    Matthew W Flounders et al.
    Neural dynamics during prior experience-guided visual ambiguity resolution reveal early stimulus-feature processing and late content-specific recognition processing involving large-scale brain networks.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    DDM1 and Lsh remodelers allow methylation of DNA wrapped in nucleosomes

    David B Lyons, Daniel Zilberman
    Nucleosomes and linker histones block eukaryotic cytosine methylation.
    1. Neuroscience

    How prior preferences determine decision-making frames and biases in the human brain

    Alizée Lopez-Persem et al.
    Model-based analyses of choice behavior and fMRI activity revealed that prior preferences generate default policies, which frame the decision value signal encoded in the vmPFC, and shift vmPFC pre-choice activity so as to induce a decision bias toward default options.