Alterations to brain network communication leading to a progressive loss in descending inhibitory modulation of the spinal cord is a key determinate of pain state development following peripheral nerve injury.

Out breeding depression in Caenorhabditis tropicalis is due to common maternal-offspring incompatibilities that interact with a highly heterogeneous genetic background and may provide a short-term advantage to inbreeding.

The ability of animals to adjust to thermal stress is critical for survival under global warming, yet the adjustment process and scope have (until now) remained obscure in marine fishes.

Changing which layer 6 neurons are active during sensory tasks disrupts the detection and encoding of changes, but still allows integration of sensory information in the absence of changes.

Optogenetic and electrical low-frequency stimulation in the sclerotic hippocampus prevents the emergence of spontaneous focal and evoked generalized seizures in a mouse epilepsy model.

A detailed molecular mechanism on lipid flipping from outside leaflet to the inside leaflet of the eukaryotic plasma membrane bilayer.

The INM protein LAP1B, an activator of Torsin ATPases, is a chromatin-binding factor that erroneously persists on mitotic chromatin if Torsin functionality is compromised, inducing chromosome segregation defects and binucleation.

Sleep-related hemodynamic signals are much larger than those in the awake brain, so it is crucial to monitor the arousal state during studies of spontaneous activity.

During sleep, the brain experiences large fluctuations in blood volume and altered coupling between neural and vascular signals.

Successful autism spectrum disorder gene discovery using forward genetics identifies KDM5A, which encodes a histone H3 lysine 4 demethylase, as a disease gene.