375 results found
    1. Neuroscience

    In vivo detection of optically-evoked opioid peptide release

    Ream Al-Hasani et al.
    In vivo detection of optically evoked endogenous opioid peptides reveals anatomically distinct release profiles.
    1. Cancer Biology
    2. Immunology and Inflammation

    Topography of cancer-associated immune cells in human solid tumors

    Jakob Nikolas Kather et al.
    Spatial patterns of lymphoid and myeloid cells in human solid tumors differ between cancer types, yielding a new classification of anti-tumor host response.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Transcriptional and epigenomic landscapes of CNS and non-CNS vascular endothelial cells

    Mark F Sabbagh et al.
    Genome-wide integration of transcriptome, accessible chromatin, and DNA methylome data from vascular endothelial cells lays the foundation for understanding the gene regulatory circuits that generate organ-specific vascular specialization.
  1. Annual report: Looking back on 2017

    A reflection on eLife's achievements in 2017, notably in convening and supporting communities, modernising technology for research communication and partnering with early-career researchers.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Structural basis for Scc3-dependent cohesin recruitment to chromatin

    Yan Li et al.
    The Cohesin subunit Scc3 contains a hook-shaped domain that binds to DNA substrate, thus revealing that Cohesin-chromatin transactions are driven not only by topological interactions, but also by direct protein-DNA contacts.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Coevolution-based inference of amino acid interactions underlying protein function

    Victor H Salinas, Rama Ranganathan
    A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.
    1. Cancer Biology
    2. Cell Biology

    An alternative splicing switch in FLNB promotes the mesenchymal cell state in human breast cancer

    Ji Li et al.
    Splicing by QKI and RBFOX1 regulates the function of the actin-binding protein FLNB by creating an isoform frequently observed in human cancers that dictates tumor cell plasticity.
    1. Biochemistry and Chemical Biology

    An assay for de novo kinetochore assembly reveals a key role for the CENP-T pathway in budding yeast

    Jackie Lang et al.
    An assay to assemble kinetochores de novo was developed and used to identify the role of the CENP-T pathway.
    1. Structural Biology and Molecular Biophysics

    Structure of the human volume regulated anion channel

    Jennifer M Kefauver et al.
    The homomeric structure of human SWELL1 (LRRC8A) provides insights into properties of a novel chloride channel family.
    1. Biochemistry and Chemical Biology

    Efficient analysis of mammalian polysomes in cells and tissues using Ribo Mega-SEC

    Harunori Yoshikawa et al.
    Translationally active polysomes from mammalian cells/tissues are successfully separated with rapidity, high efficiency and exceptional reproducibility by a SEC-based approach, an accessible alternative to the conventional sucrose density gradient analysis.

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