156 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    The nanoscale organization of the Nipah virus fusion protein informs new membrane fusion mechanisms

    Qian Wang, Jinxin Liu ... Qian Liu
    Single-molecule localization imaging shows that the Nipah virus fusion protein forms nanoscale clusters on cell and viral membranes that favor membrane fusion activation.
    1. Ecology
    2. Computational and Systems Biology

    Microbes with higher metabolic independence are enriched in human gut microbiomes under stress

    Iva Veseli, Yiqun T Chen ... A Murat Eren
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Cancer Biology

    Proteogenomic analysis of air-pollution-associated lung cancer reveals prevention and therapeutic opportunities

    Honglei Zhang, Chao Liu ... Gaofeng Li
    MAD1 and TPRN were identified as novel potential therapeutic targets of lung adenocarcinoma in female never-smokers from the Xuanwei area.
    1. Cell Biology
    2. Immunology and Inflammation

    Science Forum: Antibody characterization is critical to enhance reproducibility in biomedical research

    Richard A Kahn, Harvinder Virk ... Skye Longworth
    There is an ongoing need for researchers and all stakeholders to better understand issues surrounding antibody characterization to improve the quality and reproducibility of research that employs these reagents.
    1. Cancer Biology

    Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

    Kyle Spinler, Michael Hamilton ... Tannishtha Reya
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology

    Replication of null results: Absence of evidence or evidence of absence?

    Samuel Pawel, Rachel Heyard ... Leonhard Held
    Equivalence testing and Bayes factors are informative statistical methods for analyzing replication studies of original studies with null results, and can address the limitations of the commonly used non-significance criterion.
    1. Cancer Biology

    STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer

    Stephen D'Amico, Varvara Kirillov ... Nancy C Reich
    Results show that STAT3 and KRAS jointly regulate oncogenic dependency of mutant KRAS cancer cells.
    1. Chromosomes and Gene Expression

    Integrative analysis of DNA replication origins and ORC-/MCM-binding sites in human cells reveals a lack of overlap

    Mengxue Tian, Zhenjia Wang ... Chongzhi Zang
    The ~20,000 origins of replication in human cell lines that are reproducibly identified by multiple techniques in multiple cell lines are distant from known origin recognition complex and MCM2-7-binding sites.
  1. eLife Magazine: 300 Feature Articles and counting

    Feature Articles in eLife cover research culture, diversity and inclusion, and a wide range of other topics related to science and research.
    1. Cell Biology

    An open-source, high-resolution, automated fluorescence microscope

    Ando Christian Zehrer, Ana Martin-Villalba ... Helge Ewers
    High-quality fluorescence live-cell and single molecule imaging via computer-controlled, user-assembled microscope that fits in incubator, can in large parts be 3D printed and employs open source software and electronics.

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