682 results found
    1. Evolutionary Biology
    2. Genetics and Genomics

    Drosophila seminal sex peptide associates with rival as well as own sperm, providing SP function in polyandrous females

    Snigdha Misra, Mariana F Wolfner
    A seminal protein from a mating-male can bind sperm previously stored in his mate, providing direct benefits to the sperm from the prior male that mated with her.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Antagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53

    Syafiq Abd Wahab, Dirk Remus
    The mechanism of Dbf4-dependent kinase (DDK) recruitment to replication origins and its regulation by the checkpoint have been identified.
    1. Microbiology and Infectious Disease

    Host sirtuin 2 as an immunotherapeutic target against tuberculosis

    Ashima Bhaskar et al.
    The inhibition of host Sirtuin-2 by AGK2 restricts mycobacterial growth in vivo by modulation of host transcriptome leading to activation of protective immune responses.
    1. Neuroscience

    Homeostatic plasticity fails at the intersection of autism-gene mutations and a novel class of common genetic modifiers

    Özgür Genç et al.
    Forward genetic screens define a novel genetic landscape by which diverse, unrelated autism risk genes may converge to commonly affect the robustness of synaptic transmission.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Peroxiredoxin promotes longevity and H2O2-resistance in yeast through redox-modulation of protein kinase A

    Friederike Roger et al.
    The major cytosolic yeast peroxiredoxin Tsa1 controls aging and H2O2-resistance by inhibiting protein kinase A through a conserved cysteine in the catalytic subunit activation loop and not by scavenging H2O2.
    1. Human Biology and Medicine
    2. Neuroscience

    Deciphering the neural signature of human cardiovascular regulation

    Jorge Manuel et al.
    At least three hypothalamic subsystems are involved in cardiovascular regulation in humans.
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative modelling approach to zebrafish pigment pattern formation

    Jennifer P Owen et al.
    A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.
    1. Cell Biology

    Ribosome collisions trigger cis-acting feedback inhibition of translation initiation

    Szymon Juszkiewicz et al.
    Ribosome collisions along an mRNA are shown to recruit factors that prevent additional ribosomes from initiating translation on that mRNA, thereby providing time to resolve the collision.
    1. Neuroscience

    Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

    Naomi AK Hanemaaijer et al.
    High-speed calcium imaging from the axon initial segment shows that sodium channels are in part permeable to calcium ions.
    1. Immunology and Inflammation
    2. Neuroscience

    A new genetic strategy for targeting microglia in development and disease

    Gabriel L McKinsey et al.
    P2ry12-CreER robustly and specifically labels microglia in fate-mapping and ribosomal profiling experiments, revealing new markers for myeloid subpopulations in the central nervous system.

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