712 results found
  1. Meta-research

    Meta-Research: A Collection of Articles

    Edited by Peter A Rodgers
    The study of science itself is a growing field of research.
  2. December 2014

    Episode 16: December 2014

    In this episode we hear about reproducibility, drug resistance, cells without walls, gene transfer, interspecies signalling, and stem cells.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

    Lei Yang et al.
    Genomes take advantage of the gene-duplicating ability of retroelements to birth novel innate immune defense genes.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures and functional properties of CALHM channels of the human placenta

    Katarzyna Drożdżyk et al.
    Members of the calcium homeostasis modulator family expressed in the placenta form large channels with unknown activation properties that harbor a lipid bilayer on the inside of a cylindrical pore.
    1. Computational and Systems Biology
    2. Neuroscience

    The natverse, a versatile toolbox for combining and analysing neuroanatomical data

    Alexander Shakeel Bates et al.
    Open source software enables neuroscientists to integrate single neuron or synaptic-resolution datasets from different imaging modalities to analyse morphology and connectivity at the scale of whole brains and connectomes.
    1. Cell Biology
    2. Computational and Systems Biology

    DASC, a sensitive classifier for measuring discrete early stages in clathrin-mediated endocytosis

    Xinxin Wang et al.
    A new user-intervention-free classification, using single-fluorescent markers, measures conventionally unmeasureable phenotypes in early stages during clathrin-mediated endocytosis.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

    Nairita Maitra et al.
    Extensive molecular profiling shows how loss of highly similar, paralogous ribosomal proteins lead to distinct phenotypic outputs, through translational control of specific mRNAs.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development

    Irina Matos et al.
    Progenitors establish a single-cell length WNT morphogen gradient to transmit signals directionally and differentially to neighbors.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Hfq CLASH uncovers sRNA-target interaction networks linked to nutrient availability adaptation

    Ira Alexandra Iosub et al.
    High-throughput RNA-RNA interaction analysis uncovers many novel sRNA-target interactions at various growth stages in Escherichia coli.
    1. Developmental Biology

    A complex regulatory landscape involved in the development of mammalian external genitals

    Ana Rita Amândio et al.
    In vertebrates, large regulatory landscapes sometimes behave as coherent regulatory units, which may explain the lack of effect sometimes observed when single enhancer sequences are deleted in isolation.

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