Clair R Henthorn, Paul M Airs ... Mostafa Zamanian
A single-cell gene expression atlas in a human parasitic nematode provides new insights into the distribution of anthelmintic targets and the origins of secretory molecules with diagnostic and therapeutic potential at the host–parasite interface.
Franck Ladam, William Stanney ... Charles G Sagerström
TALE transcription factors bind different genomic motifs and function together with different protein partners at different stages of zebrafish embryogenesis.
Jamie Moore-Fried, Mahinder Paul ... Gregoire Lauvau
CD169+ macrophages in the bone marrow of malaria-infected mice uptake infected red blood cells, and establish a functional interaction that is required to activate plasmacytoid dendritic cells to secrete type I interferon and leave the bone marrow.
Miguel Ramirez, Yuliya Badayeva ... Daniel Goldowitz
An analysis of enhancer activity during mouse cerebellar development provides an invaluable resource for studying gene expression regulation by enhancers in the developing cerebellum and delivers a rich dataset of novel gene-enhancer associations providing a basis for future in-depth studies.
Sina Atashpaz, Sara Samadi Shams ... Vincenzo Costanzo
ATR protects stem cell genomes by activating a transcriptional response mediated by totipotency genes, conferring trophoblast differentiation potential, the derepression of which in somatic cells might favour cancer features emergence.
PRDM13, a transcriptional repressor, antagonizes activity of basic-helix-loop-helix transcriptional activators and protects the developing spinal cord from aberrant expression of ventral-restricted cell-type regulators to generate the correct composition of neurons in the dorsal spinal cord.
The disease-associated RNA binding protein Nab2 is required to inhibit m6A RNA methylation in female Drosophila neuronal tissue and controls key splicing events such as sex-specific splicing of the Sex-lethal RNA.
