814 results found
    1. Genetics and Genomics
    2. Neuroscience

    Integrated transcriptomic and neuroimaging brain model decodes biological mechanisms in aging and Alzheimer’s disease

    Quadri Adewale et al.
    Identification of causal genes and their effects on other biological determinants untangles the complexities of aging and Alzheimer's and can facilitate drug discovery for sustaining healthy aging and treating Alzheimer's.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    The biphasic and age-dependent impact of klotho on hallmarks of aging and skeletal muscle function

    Zachary Clemens et al.
    Transcriptomic analysis using a novel information-based network entropy approach provides mechanistic insights into the ability of Klotho to successfully ameliorate age-related sarcopenia in old mice, but not oldest-old mice.
    1. Genetics and Genomics
    2. Neuroscience

    Propensity for somatic expansion increases over the course of life in Huntington disease

    Radhia Kacher et al.
    Somatic instability of the CAG repeat increases progressively with age and disease progression in Huntington disease mutation carriers, starting with low levels in fetal brain tissues.
    1. Cell Biology
    2. Physics of Living Systems

    How cells determine the number of polarity sites

    Jian-geng Chiou et al.
    Minimal essential features of Rho GTPase systems are elucidated that regulate the number of distinct domains developed by a cell’s polarity machinery, which in turn governs cell shape.
    1. Biochemistry and Chemical Biology

    De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition

    Erich Stefan et al.
    By random nonstandard peptide integrated discovery, combinatorial macrocyclic peptides were leavaged that target a heterodimeric ABC transport complex and explore fundamental principles of the substrate translocation cycle.
    1. Cell Biology
    2. Developmental Biology

    EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice

    Yuki Osawa et al.
    EXOC1 contributes to the proper differentiation balance of spermatogonial stem cells and spermatocyte syncytia formation by regulating the morphology of male germ cells.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Single mosquito metatranscriptomics identifies vectors, emerging pathogens and reservoirs in one assay

    Joshua Batson et al.
    How large-scale single mosquito metatranscriptomics can define the mosquito’s complex microbiota and its blood meal sources, and contribute critical epidemiological information needed to control vector borne disease transmission, is shown.
    1. Cell Biology

    A robust method for particulate detection of a genetic tag for 3D electron microscopy

    James Rae et al.
    Development of a new system for gold particle detection of a genetic tag for electron microscopy.
    1. Neuroscience

    DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

    Eva On-Chai Lau et al.
    DIAPH3 safeguards integrity of microtubule cytoskeleton during division of neural progenitor cells.
    1. Computational and Systems Biology
    2. Ecology

    TRex, a fast multi-animal tracking system with markerless identification, and 2D estimation of posture and visual fields

    Tristan Walter, Iain D Couzin
    Being fast, memory efficient, easy to use, and with powerful integrated tools, TRex will lower barriers of entry into, and enable more ambitious approaches to, the quantitative study of behavior.

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