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    1. Developmental Biology
    2. Neuroscience

    R7 photoreceptor axon targeting depends on the relative levels of lost and found expression in R7 and its synaptic partners

    Jessica Douthit et al.
    R7 photoreceptors require the endosomal protein Lost and Found to form stable connections only when this protein is also present in neurons that are synaptic partners of R7.
    1. Ecology
    2. Plant Biology

    Genetic variation, environment and demography intersect to shape Arabidopsis defense metabolite variation across Europe

    Ella Katz et al.
    Measurements of specialized metabolites across a population of 800 natural Arabidopsis thaliana accessions revealed different pressures and evolutionary processes that shaped their variation and distribution across Europe.
    1. Biochemistry and Chemical Biology

    Dwarf open reading frame (DWORF) is a direct activator of the sarcoplasmic reticulum calcium pump SERCA

    M'Lynn E Fisher et al.
    Activation of the sarcoplasmic reticulum calcium pump and enhancement of cellular calcium homeostasis by dwarf open reading frame reveal how this small membrane protein opposes phospholamban inhibitory function in cardiac muscle.
    1. Cancer Biology

    Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer

    Andrea Sacchetti et al.
    Colon cancer cells disseminate and colonize distant organ sites along the invasion-metastasis cascade by transiently activating intermediate epithelial to mesenchymal transition states through distinct transcriptional trajectories.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Allosteric conformational ensembles have unlimited capacity for integrating information

    John W Biddle et al.
    The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
    1. Epidemiology and Global Health
    2. Medicine

    An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

    Torsten Dahlén et al.
    The relationship between blood groups and disease is detangled, without preconceived ideas, using population-wide data, with millions of participants and lifetime follow-up, identifying not only previously known relationships but also new insights.
    1. Computational and Systems Biology
    2. Plant Biology

    An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time

    Katie Abley et al.
    Arabidopsis shows extensive genetic diversity in germination time distributions, which can be explained by the underlying ABA/GA network functioning as a noisy bistable switch.
    1. Neuroscience

    Distinct protocerebral neuropils associated with attractive and aversive female-produced odorants in the male moth brain

    Jonas Hansen Kymre et al.
    Electrophysiological and morphological identification of individual pheromone projection neurons in male moth reveals a coding system for optimizing mate search strategy, including computation of three female-produced signals in distinct protocerebral regions.
    1. Immunology and Inflammation

    CD8+ T cell self-tolerance permits responsiveness but limits tissue damage

    Emily N Truckenbrod et al.
    Identification and characterization of the responses of T lymphocytes that are specific for 'self' tissue antigens, revealing the functional limits of immune tolerance.
    1. Neuroscience

    Perturbation of amygdala-cortical projections reduces ensemble coherence of palatability coding in gustatory cortex

    Jian-You Lin et al.
    Blocking input from basolateral amygdala to gustatory cortex (GC) severely reduces the coherence of GC ensemble activity, which negatively affects epochal dynamics involved in driving palatability-driven consumption.