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    1. Developmental Biology
    2. Neuroscience

    Robo2 acts in trans to inhibit Slit-Robo1 repulsion in pre-crossing commissural axons

    Timothy A Evans et al.
    The Roundabout2 receptor acts non-autonomously to promote commissural axons to cross the midline by antagonizing Slit-dependent axon repulsion.
    1. Neuroscience

    Human VMPFC encodes early signatures of confidence in perceptual decisions

    Sabina Gherman, Marios G. Philiastides
    Simultaneous EEG-fMRI reveals neural representations of decision confidence unfolding prior to explicit perceptual choices, in a region of the ventromedial prefrontal cortex typically linked to reward processing and value-based decisions.
    1. Chromosomes and Gene Expression

    A gene-specific T2A-GAL4 library for Drosophila

    Pei-Tseng Lee et al.
    A library of a thousand gene-specific intronic GAL4 insertions was generated, which caused a severe loss of function, permitted the assessing of gene expression, allowed the rescue of mutated gene with UAS-cDNA constructs, and provided a tool for the reversion of mutant phenotypes in specific cells or tissues.
    1. Cell Biology

    Prickle isoforms determine handedness of helical morphogenesis

    Bomsoo Cho et al.
    The Pkpk and Pksple isoforms of the Prickle protein determine right- or left-handed bristle morphogenesis by coupling Frizzled/Vang signaling to the Fat/Dachsous PCP directional signal in opposite directions.
    1. Cell Biology

    In vitro reconstitution of branching microtubule nucleation

    Ammarah Tariq et al.
    Purification of two conserved protein complexes, the γ-TuRC and Augmin, using a simple affinity technique, demonstrates that they are necessary and sufficient for the essential phenomenon of branching microtubule nucleation.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification

    Matthew T Parker et al.
    Sequencing mRNA directly with nanopores can reveal the authentic combinations of multiple mRNA processing events in full-length mRNA molecules in addition to identifying base modifications.
    1. Developmental Biology
    2. Neuroscience

    Two receptor tyrosine phosphatases dictate the depth of axonal stabilizing layer in the visual system

    Satoko Hakeda-Suzuki et al.
    Two receptor tyrosine phosphatases having overlapping function for the determination of the final axon stabilizing layer is encoded for their cumulative cytoplasmic activity and ligand specificity in the visual system.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    The mechanism of variability in transcription start site selection

    Libing Yu et al.
    Variability in bacterial transcription start site selection involves DNA “scrunching” and “anti-scrunching,” which may represent a general mechanism for start site selection in all organisms.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection

    Magdalena Steinrueck, Călin C Guet
    Experimental evolution reveals how adaptation by increased expression of a gene depends on a combination of simple genetic properties of the gene's neighbors on the DNA.
    1. Cancer Biology
    2. Cell Biology

    IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation

    Li Pan et al.
    Unbiased analyses highlight context-specific crosstalk between Notch, DNA damage response genes, and PP2A, and provide a roadmap for understanding how Notch induces squamous cell differentiation.