2,141 results found
    1. Developmental Biology
    2. Neuroscience

    Maf and Mafb control mouse pallial interneuron fate and maturation through neuropsychiatric disease gene regulation

    Emily Ling-Lin Pai et al.
    Maf and Mafb differentially regulate MGE-derived cortical and hippocampal interneuron subtype and regional fate in part through promoting the expression of Mef2c and Pnoc during mouse embryonic neurogenesis.
    1. Cell Biology

    The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis

    Donglei Zhang, Michael Glotzer
    Activation of the key regulator of cytokinesis, RhoA, involves an unexpected contribution by a RhoGAP domain.
    1. Cell Biology

    In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation

    Alison K Gillingham et al.
    Relocation of Rab, Ras and Rho family GTPases to the surface of mitochondria enables efficient identification of their effectors, exchange factors and GAPs by proximity biotinylation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

    Adriana E Golding et al.
    Through visualization of directly-labeled RhoGTPase both in vitro and in vivo, RhoGDI is found to spatiotemporally regulate RhoGTPase activity through the extraction of active RhoGTPase.
    1. Ecology

    Acknowledging selection at sub-organismal levels resolves controversy on pro-cooperation mechanisms

    Wenying Shou
    Building on previous work (Momeni et al., 2013), it is shown that recognizing the hierarchical organization of biological systems resolves the ongoing controversy on pro-cooperation mechanisms.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Neuroscience

    Human observers have optimal introspective access to perceptual processes even for visually masked stimuli

    Megan A K Peters, Hakwan Lau
    Despite the widely held belief among researchers in consciousness that healthy observers can show unconscious perception, a study using a novel method to control for response biases finds no evidence for this phenomenon.
    1. Neuroscience

    Neuropathological and transcriptomic characteristics of the aged brain

    Jeremy A Miller et al.
    High variability in neuropathology burden and interactions between dementia diagnosis and RNA quality present underappreciated complications when studying dementia in an aged population.
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Homing Genetic Elements: Mobile DNAs and switching mating types in yeast

    Laura N Rusche
    The gene that allows budding yeast cells to switch their mating type evolved from a newly discovered family of genes named weird HO.
    Insight
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