1,053 results found
    1. Stem Cells and Regenerative Medicine

    Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis

    Katherine T Best et al.
    Adult Scleraxis-lineage cells are not required for successful tendon healing but are required for maintenance of tendon homeostasis.
    1. Developmental Biology
    2. Neuroscience

    Glial insulin regulates cooperative or antagonistic Golden goal/Flamingo interactions during photoreceptor axon guidance

    Hiroki Takechi et al.
    Timely regulation of growth cone dynamics, including filopodial and cytoskeletal rearrangements through phosphorylation signals from glial cells, shapes the photoreceptor axon targeting.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Distinct clonal evolution of B-cells in HIV controllers with neutralizing antibody breadth

    Deniz Cizmeci et al.
    Extended somatic hypermutation and clonal evolution associated with antibody neutralization breath in HIV controllers with low plasma viral loads provide promise for HIV vaccine development.
    1. Microbiology and Infectious Disease

    Vibrio deploys type 2 secreted lipase to esterify cholesterol with host fatty acids and mediate cell egress

    Suneeta Chimalapati et al.
    Considering the course of a pathogen's evolution, there appears to be interplay between secretion systems, providing unique, synergistic mechanisms to support a successful lifestyle for possibly pathogenesis, symbiosis and/or parasitosis.
    1. Developmental Biology
    2. Neuroscience

    Extrinsic activin signaling cooperates with an intrinsic temporal program to increase mushroom body neuronal diversity

    Anthony M Rossi, Claude Desplan
    The activin ligand myoglianin acts as a temporal extrinsic cue to regulate the intrinsic temporal factor Imp in mushroom body neuroblasts, increasing neuronal diversity by specifying the α’β’ fate.
    1. Stem Cells and Regenerative Medicine

    Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

    Mi-Sun Lee et al.
    Tgfb3 inhibits Muller glial cell reprogramming and drives Muller cell quiescence in the injured zebrafish retina, thereby inhibiting retina regeneration.
    1. Computational and Systems Biology
    2. Neuroscience

    Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

    Amin Haghani et al.
    Transcriptome analysis of mouse brain revealed that the APOE4 allele and sex can alter air pollution neurotoxicity in adults.
    1. Neuroscience

    Interactions between Dpr11 and DIP-γ control selection of amacrine neurons in Drosophila color vision circuits

    Kaushiki P Menon et al.
    The survival of Drosophila amacrine neurons is controlled by neurotrophic signaling mediated by interactions between the cell surface protein DIP-γ and its partner Dpr11, which is expressed on presynaptic photoreceptors.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Viral miRNA adaptor differentially recruits miRNAs to target mRNAs through alternative base-pairing

    Carlos Gorbea et al.
    iRICC, a new method to identify RNA-RNA interactions in vivo, provides mechanistic insight into the function of a viral non-coding RNA.
    1. Physics of Living Systems

    Negative reciprocity, not ordered assembly, underlies the interaction of Sox2 and Oct4 on DNA

    John W Biddle et al.
    Rigorous reanalysis of single-molecule data yields evidence for energy expenditure in the interaction of transcription factors on DNA.

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