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MT plus-end-mediated recruitment of a cortical pool of ECT2 trigger RhoA activation upon contact, which results in localized contractility during cytokinesis.

Mfn2 depletion upregulates cytosolic Ca²⁺ in mouse fibroblast cells, leading to RhoA and nonmuscle myosin II overactivation and a prominent peripheral actin band structure, which is dependent on the contractile force on the cell–substrate interface.

In fission yeast cell wall stress triggers a cytokinesis blockage specifically in the onset of actomyosin ring constriction.

FOXM1 is co-expressed with its bidirectional gene partner RHNO1, and the two genes promote DNA repair, cell growth and survival, and chemotherapy resistance in ovarian cancer.

New methods to directly visualize Rho GTPases reveal how a protein called RhoGDI regulates the activity of these 'molecular switches' at the plasma membrane.

Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.

Stem cell-derived retinal organoids are a useful tool to understand the pathobiology of devastating retinal degenerations and can aid to identify and validate therapeutics to promote rescue.

The p75 neurotrophin receptor prevents the migration of the granule cell precursors away from its mitogenic niche in the external granule layer of the cerebellum, by maintaining a pool of undifferentiated cells capable of responding to mitogenic signals.

The allele-specific gene-editing drug is expected to make RHO-T17M-associated retinitis pigmentosa therapy a reality.

Genetic and pharmacological tools are used to dissect the mechanisms by which the presynaptic actin cytoskeleton facilitates membrane internalization at synapses and, thereby, neurotransmission.