Through visualization of directly-labeled RhoGTPase both in vitro and in vivo, RhoGDI is found to spatiotemporally regulate RhoGTPase activity through the extraction of active RhoGTPase.

DeepFly3D, a deep learning-based software, measures limb and appendage movements in tethered, behaving Drosophila and enables precise behavioral measurements during neural recordings, stimulation, and other biological experiments.

Activation of the key regulator of cytokinesis, RhoA, involves an unexpected contribution by a RhoGAP domain.

Anatomical tracing and physiological recordings reveal neuronal pathways through which the cerebellum may influence hippocampal activity.

Small Rho GTPases confer up- and downregulation in mammalian plexin signaling by differential interactions with cell membrane.

PDZ-RhoGEF controls adipose tissue abundance and whole body metabolism.

Structures of the death domain of the p75 neurotrophin receptor in complex with downstream effectors show how competitive protein-protein interactions orchestrate the hierarchical activation of downstream pathways in non-catalytic receptors.

Shigella infection induces a calpain-mediated loss of SUMO conjugates that promotes bacterial entry.

The RhoGTPase domain containing protein GRAF recruits to the cleavage furrow during myosin II assembly to hydrolyze Rho-GTP and restrict actomyosin contractility for regulating the time of onset of constriction during Drosophila cellularization.

Centrosomal Aurora A (AIR-1), together with cortical actomyosin flows, induces polarization of ECT-2, the activator of RHO-1, during polarization and cytokinesis, in order to promote furrow formation.