24 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

    Adriana E Golding et al.
    Through visualization of directly-labeled RhoGTPase both in vitro and in vivo, RhoGDI is found to spatiotemporally regulate RhoGTPase activity through the extraction of active RhoGTPase.
    1. Developmental Biology

    Spatiotemporal recruitment of RhoGTPase protein GRAF inhibits actomyosin ring constriction in Drosophila cellularization

    Swati Sharma, Richa Rikhy
    The RhoGTPase domain containing protein GRAF recruits to the cleavage furrow during myosin II assembly to hydrolyze Rho-GTP and restrict actomyosin contractility for regulating the time of onset of constriction during Drosophila cellularization.
    1. Cell Biology
    2. Computational and Systems Biology

    Periodic propagating waves coordinate RhoGTPase network dynamics at the leading and trailing edges during cell migration

    Alfonso Bolado-Carrancio et al.
    Different RhoA and Rac1 dynamics at the cell front and rear are coordinated through periodic GTPase waves, which define the minimal autonomous biochemical machinery necessary and sufficient for cell migration.
    1. Developmental Biology

    Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

    Bechara Saykali et al.
    At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning

    Koray Kırlı et al.
    A new resource quantifying the distribution of 5,000 individual proteins between nucleus and cytoplasm, as well as identifying 2,800 yeast, human and frog proteins that are exported from the nucleus by the exportin CRM1/Xpo1.
    1. Neuroscience

    Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1

    Leanne M Holt et al.
    Brain-derived neurotrophic factor (BDNF)/TrkB.T1 signaling contributes to astrocyte morphological maturation, with implications for neuronal synaptogenesis and function and astrocyte functional maturation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Efficient protein targeting to the inner nuclear membrane requires Atlastin-dependent maintenance of ER topology

    Sumit Pawar et al.
    Efficient targeting of membrane proteins from the endoplasmic reticulum (ER) to the inner nuclear membrane depends on GTP hydrolysis by Atlastin GTPases and their function in maintaining an interconnected topology of the ER network.
    1. Developmental Biology
    2. Neuroscience

    The adhesion-GPCR BAI1 shapes dendritic arbors via Bcr-mediated RhoA activation causing late growth arrest

    Joseph G Duman et al.
    The adhesion-GPCR BAI1 shapes dendritic arbors in the hippocampus by associating with Bcr late in development and stimulating its RhoA-GEF activity, resulting in dendritic growth arrest.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

    Lars Langemeyer et al.
    Analysis of multiple guanine exchange factors shows that Rab activation can occur via a number of mechanistically distinct GDP-release pathways.
    1. Cell Biology
    2. Neuroscience

    Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

    Shataakshi Dube O'Neil et al.
    Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.

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