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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of death domain signaling in the p75 neurotrophin receptor

    Zhi Lin et al.
    Structures of the death domain of the p75 neurotrophin receptor in complex with downstream effectors show how competitive protein-protein interactions orchestrate the hierarchical activation of downstream pathways in non-catalytic receptors.
    1. Genetics and Genomics

    Point of View: Bioengineering horizon scan 2020

    Luke Kemp et al.
    20 emerging issues in bioengineering that will have profound impacts on society have been identified.
    1. Neuroscience

    On cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus

    Robson Scheffer-Teixeira, Adriano BL Tort
    Phase-locking of hippocampal theta and gamma waves has been proposed to support memory formation, but an analysis using robust statistical methods finds no convincing evidence for the phenomenon.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    MicroCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system

    Matthew Hur et al.
    Deep skeletal phenotyping in adult zebrafish reveals enhanced sensitivity of phenomic patterns in discriminating mutant populations.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    SCGN deficiency results in colitis susceptibility

    Luis F Sifuentes-Dominguez et al.
    A novel mutation in SCGN is associated with risk for inflammatory bowel disease and implicates the intestinal neuroendocrine compartment in the pathogenesis of this disorder.
    1. Structural Biology and Molecular Biophysics

    Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes

    Eshwar R Tammineni et al.
    Calcium-driven protein changes, causing glycogenolysis, poor synthesis, and diminished content of glycogen, along with diminished glucose transporters, lead to hyperglycemia in patients prone to calcium leaks from intracellular muscle stores.
    1. Cell Biology
    2. Developmental Biology

    TMEM79/MATTRIN defines a pathway for Frizzled regulation and is required for Xenopus embryogenesis

    Maorong Chen et al.
    TMEM79 targets frizzled receptor for degradation through inhibiting USP8 and is required for Xenopus embryogenesis.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Global biogeographic sampling of bacterial secondary metabolism

    Zachary Charlop-Powers et al.
    Pyro-sequencing of two genes involved in bacterial secondary metabolism provides new insights into the rich reservoir of biologically active small molecules found in environmental bacteria.
    1. Cell Biology
    2. Neuroscience

    Transverse tubule remodeling enhances Orai1-dependent Ca2+ entry in skeletal muscle

    Antonio Michelucci et al.
    Structural and functional analyses show that transverse tubule association with stacks of sarcoplasmic reticulum enhances Orai1-dependent Ca2+ entry to replenish Ca2+ stores, maintain Ca2+ release, and maximize force during exercise.
    1. Chromosomes and Gene Expression

    The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae

    Evan P Hass, David C Zappulla
    In yeast, the secondary pathway for recruiting telomerase to chromosome ends requires a component of telomeric transcriptionally silent chromatin.