818 results found
    1. Epidemiology and Global Health

    A century of trends in adult human height

    NCD Risk Factor Collaboration (NCD-RisC)
    Height in early adulthood is an indicator that integrates across different dimensions of sustainable human development with links to health and longevity, nutrition, education and economic productivity.
    1. Developmental Biology
    2. Neuroscience

    Supporting cells remove and replace sensory receptor hair cells in a balance organ of adult mice

    Stephanie A Bucks, Brandon C Cox ... Jennifer S Stone
    Cell fate-mapping with genetically-modified mouse models and cellular markers demonstrates that sensory hair cells in the vestibular portion of the inner ear are a dynamic population in adult mice that undergo cell death and replacement under normal conditions.
    1. Stem Cells and Regenerative Medicine

    Human-induced pluripotent stem cell-derived microglia integrate into mouse retina and recapitulate features of endogenous microglia

    Wenxin Ma, Lian Zhao ... Wei Li
    Transplanted human iPSC-derived microglial cells with immune responses and phagocytic abilities integrate and occupy native microglial cell space and functionally respond to retinal injuries.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

    Ching-Lin Hsieh, Christopher P Ptak ... Yung-Fu Chang
    The antibody accessibility of the leptospiral surface protein, LigB, provides a guide for the rational design of improved recombinant chimeric vaccine antigens displayed on a single domain scaffold.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Filopodia powered by class x myosin promote fusion of mammalian myoblasts

    David W Hammers, Cora C Hart ... H Lee Sweeney
    Filopodia driven by class X myosin promote the fusion of mammalian myoblasts in the development of skeletal muscle and are important for the regeneration of skeletal muscle following muscle injury.
    1. Computational and Systems Biology
    2. Neuroscience

    Microsaccadic sampling of moving image information provides Drosophila hyperacute vision

    Mikko Juusola, An Dau ... Jouni Takalo
    New experiments and theory reveal how the ability to see image details depends upon photoreceptor function and eye movements, and how fruit flies (Drosophila) see spatial details beyond the optical limit of their compound eyes.
    1. Biochemistry and Chemical Biology

    Syntaxin-6 delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates

    Daljit Sangar, Elizabeth Hill ... Jan Bieschke
    A new native prion protein aggregation assay shows that syntaxin-6, a risk factor for sporadic Creutzfeldt–Jakob disease, delays prion protein fibril formation and prolongs the presence of toxic aggregation intermediates.
    1. Computational and Systems Biology

    Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies

    Wen Yan, Saad Ansari ... Michael Shelley
    aLENS implements new parallel methods to resolve cytoskeletal assembly dynamics with high stability, physical consistency, and scalability.
    1. Cell Biology
    2. Evolutionary Biology

    Lifespan extension in female mice by early, transient exposure to adult female olfactory cues

    Michael Garratt, Ilkim Erturk ... Richard A Miller
    Early-life exposure to conspecific urine and bedding extends the lifespan of female mice, indicating that social chemosensory cues can influence aging in a mammal.

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